Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.
Behavior in the open field predicts the number of KCl-induced cortical spreading depressions in rats.
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DOI：
10.1016/j.bbr.2012.08.004
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发表时间：
2013-01-01
影响因子：
2.7
通讯作者：
Schoenen, Jean
中科院分区：
文献类型：
--
作者：
Bogdanov, Volodymyr Borysovych;Bogdanova, Olena Viktorivna;Koulchitsky, Stanislav Vladimirovich;Chauvel, Virginie;Multon, Sylvie;Makarchuk, Mykola Yukhymovych;Brennan, Kevin Christopher;Renshaw, Perry Franklin;Schoenen, Jean
众所周知，焦虑症与偏头痛共存，而皮质扩散抑制（CSD）是偏头痛先兆最可能的原因。为了寻找 CSD 易感性与焦虑之间可能存在的相关性，我们对长期接受预防性抗偏头痛药物丙戊酸盐或核黄素治疗的雄性 Sprague-Dawley 大鼠进行了旷场试验。避开露天室中心区域的动物和探索活动（即饲养）较少的动物被认为更加焦虑。治疗 4 周后，通过在枕叶皮质上应用 1 M KCl 来引发 CSD，并将 2 小时内发生的 CSD 数量与之前评估的旷场行为进行比较。较高的焦虑样行为与较高的 KCl 诱发的 CSD 频率显着相关。在经盐水处理的动物中，CSD 更频繁的动物饲养次数更少 (R= -1.00)。丙戊酸钠组（R= -0.83；p<0.005）和核黄素治疗组（R= -0.69；p<0.05）中开放场地中心的动态发作持续时间与 CSD 数量以及两组在开放场地中心花费的总时间呈负相关（分别为 R= -0.75；p<0.05 和 R= -0.58；p<0.1）。这些结果表明，焦虑症状与 CSD 的易感性有关，并可能解释为什么它可能是先兆偏头痛的加重因素。
Anxiety disorders are known to be comorbid with migraine, and cortical spreading depression (CSD) is the most likely cause of the migraine aura. To search for possible correlations between susceptibility to CSD and anxiety we used the open field test in male Sprague-Dawley rats chronically treated with the preventive anti-migraine drugs valproate or riboflavin. Animals avoiding the central area of the open field chamber and those with less exploratory activity (i.e. rearing) were considered more anxious. After 4 weeks of treatment CSDs were elicited by application of 1 M KCl over the occipital cortex and the number of CSDs occurring over a 2 hour period was compared to the previously assessed open field behaviour. Higher anxiety-like behaviour was significantly correlated with a higher frequency of KCl-induced CSDs. In saline-treated animals, fewer rearings were found in animals with more frequent CSDs (R= −1.00). The duration of ambulatory episodes in the open field center correlated negatively with number of CSDs in the valproate group (R= −0.83; p<0.005) and in riboflavin treated group (R= −0.69; p<0.05) as well as total time spent in the open field center in both groups (R= −0.75; p<0.05 and R= −0.58; p<0.1 respectively). These results suggest that anxiety symptoms are associated with susceptibility to CSD and might explain why it can be an aggravating factor in migraine with aura.
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影响因子：
5.3
作者：
Brown, Craig E.;Sweetnam, Danielle;Nashmi, Raad
通讯作者：
Nashmi, Raad
影响因子：
9.9
作者：
Schoenen, J;Jacquy, J;Lenaerts, M
通讯作者：
Lenaerts, M
影响因子：
3.4
作者：
KURUVILLA, A;URETSKY, NJ
通讯作者：
URETSKY, NJ
影响因子：
3.8
作者：
Bouwknecht JA;Spiga F;Staub DR;Hale MW;Shekhar A;Lowry CA
通讯作者：
Lowry CA
影响因子：
5.7
作者：
Peroutka, SJ;Price, SC;Jones, KW
通讯作者：
Jones, KW