Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation.
Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation.
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高压氧可减少炎症，氧合肌肉氧气，并通过巨噬细胞和卫星细胞激活再生骨骼肌。
DOI：
10.1038/s41598-018-19670-x
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发表时间：
2018-01-22
影响因子：
4.6
通讯作者：
Yagishita K
中科院分区：
文献类型：
--
作者：
Oyaizu T;Enomoto M;Yamamoto N;Tsuji K;Horie M;Muneta T;Sekiya I;Okawa A;Yagishita K
高压氧治疗（HBO）促进软组织损伤的快速恢复。然而，其治疗机制尚不清楚。在这里，我们评估了HBO对大鼠骨骼肌损伤模型中挫伤小腿肌肉的影响。制作实验性高压氧室，损伤后给予2.5个大气压的100%氧气处理2小时/天。HBO降低挫伤肌肉早期下肢体积和肌肉湿重，并在损伤后7天提高肌肉的等长肌力。HBO在急性期抑制循环巨噬细胞的升高，进而加速巨噬细胞向挫伤肌肉的侵袭。这种环境也增加了增殖和分化卫星细胞的数量和再生肌纤维的数量。在损伤后早期，HBO刺激挫伤肌肉IL-6/STAT3通路。我们的研究结果表明，HBO在肌肉挫伤中具有减少炎症和加速肌肉生成的双重作用。
Hyperbaric oxygen treatment (HBO) promotes rapid recovery from soft tissue injuries. However, the healing mechanism is unclear. Here we assessed the effects of HBO on contused calf muscles in a rat skeletal muscle injury model. An experimental HBO chamber was developed and rats were treated with 100% oxygen, 2.5 atmospheres absolute for 2 h/day after injury. HBO reduced early lower limb volume and muscle wet weight in contused muscles, and promoted muscle isometric strength 7 days after injury. HBO suppressed the elevation of circulating macrophages in the acute phase and then accelerated macrophage invasion into the contused muscle. This environment also increased the number of proliferating and differentiating satellite cells and the amount of regenerated muscle fibers. In the early phase after injury, HBO stimulated the IL-6/STAT3 pathway in contused muscles. Our results demonstrate that HBO has a dual role in decreasing inflammation and accelerating myogenesis in muscle contusion injuries.
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影响因子：
3.3
作者：
Delos D;Maak TG;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
5
作者：
Ritter, M;Buechler, C;Schmitz, G
通讯作者：
Schmitz, G
影响因子：
3
作者：
Gejo, R;Kawaguchi, Y;Kimura, T
通讯作者：
Kimura, T
DOI：
10.1111/febs.12338
发表时间：
2013-09
期刊：
The FEBS journal
影响因子：
--
作者：
Muñoz-Cánoves P;Scheele C;Pedersen BK;Serrano AL
通讯作者：
Serrano AL
DOI：
10.1249/00005768-199307000-00012
发表时间：
1993-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
KAMI, K;MASUHARA, M;SENBA, E
通讯作者：
SENBA, E