Hatched and starved: Two chromatin compaction mechanisms join forces to silence germ cell genome.

Hatched and starved: Two chromatin compaction mechanisms join forces to silence germ cell genome.
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DOI:
10.1083/jcb.202107026
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发表时间:
2021-09-06
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Ercan S
Ercan S
中科院分区:
其他
文献类型:
--
作者:
Morao AK;Ercan S

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Morao和Ercan强调了Belew和他的同事们的工作,他们揭示了生殖细胞如何在营养饥饿期间抑制转录。动物在营养可获得性不同的环境中进化,一种适应形式是在食物短缺的条件下延迟繁殖。Belew等人。(2021年)J.细胞生物学。Https://doi.org/10.1083/jcb.202009197)报道,在线虫中,饥饿诱导的生殖细胞转录静止是通过结合两种众所周知的染色质压缩机制来实现的。
Morao and Ercan highlight work from Belew and colleagues that reveals how germ cells repress transcription during nutrient starvation. Animals evolved in environments with variable nutrient availability and one form of adaptation is the delay of reproduction in food shortage conditions. Belew et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202009197) report that in the nematode C. elegans, starvation-induced transcriptional quiescence in germ cells is achieved through a pathway that combines two well-known chromatin compaction mechanisms.
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