Crosstalk between circadian rhythms and the microbiota.
Crosstalk between circadian rhythms and the microbiota.
复制标题
昼夜节律和微生物群之间的串扰。
作者：
Pearson JA;Wong FS;Wen L
昼夜节律影响基因/蛋白质表达的每日分子振荡以及生物学和生理学方面，包括行为，体温和睡眠-觉醒周期。这些昼夜节律与许多代谢、免疫和微生物变化有关，这些变化与健康和对疾病（包括感染）的易感性有关。虽然光是昼夜节律的主要诱导物，但包括微生物群在内的其他因素也会对外周节律产生重要影响。在过去的十年中，随着分子技术的发展，许多研究人员对微生物群产生了重大兴趣，以识别大量物种及其功能。这些研究表明微生物与疾病易感性有关，其中一些研究表明微生物群的改变会导致疾病。微生物昼夜节律振荡直接或间接影响宿主的代谢和免疫。有趣的是，微生物振荡也调节宿主的昼夜节律，而宿主的昼夜节律反过来又调节微生物的组成。因此，了解昼夜节律和微生物群之间的串扰，特别是微生物对宿主的影响，具有相当大的兴趣和重要性。在这篇综述中，我们的目的是讨论昼夜微生物振荡的作用，以及它们如何影响宿主免疫。此外，我们还讨论了宿主的昼夜节律如何调节微生物的节律。我们还讨论了微生物和昼夜节律之间的潜在联系，以及如何将其用于治疗以最大限度地提高临床成功率。微生物振荡通过微生物代谢物和配体的振荡为中枢和外周生物钟提供了一个重要的反馈系统，这有助于微调振荡并确保宿主能够更快地对环境变化做出反应。微生物群中的振荡对于调节其自身功能也很重要，包括趋化性、运动性、粘附性、DNA修复和代谢。这些微生物振荡对于免疫反应的微调至关重要，我们的评论详细讨论了这一点。
Circadian rhythms influence daily molecular oscillations in gene/protein expression and aspects of biology and physiology, including behaviour, body temperature and sleep–wake cycles. These circadian rhythms have been associated with a number of metabolic, immune and microbial changes that correlate with health and susceptibility to disease, including infection. While light is the main inducer of circadian rhythms, other factors, including the microbiota, can have important effects on peripheral rhythms. The microbiota have been of significant interest to many investigators over the past decade, with the development of molecular techniques to identify large numbers of species and their function. These studies have shown microbial associations with disease susceptibility, and some of these have demonstrated that alterations in microbiota cause disease. Microbial circadian oscillations impact host metabolism and immunity directly and indirectly. Interestingly, microbial oscillations also regulate host circadian rhythms, and the host circadian rhythms in turn modulate microbial composition. Thus, it is of considerable interest and importance to understand the crosstalk between circadian rhythms and microbiota and especially the microbial influences on the host. In this review, we aim to discuss the role of circadian microbial oscillations and how they influence host immunity. In addition, we discuss how host circadian rhythms can also modulate microbial rhythms. We also discuss potential connections between microbes and circadian rhythms and how these may be used therapeutically to maximize clinical success. Microbial oscillations provide an important feedback system to both central and peripheral circadian clocks through the oscillations in microbial metabolites and ligands, which help to fine‐tune the oscillations and ensure the host can respond more quickly to environmental changes. The oscillations in microbiota are also important for modulating their own functions including chemotaxis, motility, adherence, DNA repair and metabolism. These microbial oscillations are vital for the finetuning of immune responses, which our review discusses in detail.
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影响因子：
29
作者：
Chaix A;Lin T;Le HD;Chang MW;Panda S
通讯作者：
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影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
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通讯作者：
Housseau F
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
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Toll样受体9控制鼠狼疮中的抗DNA自身抗体产生。
DOI：
10.1084/jem.20050338
发表时间：
2005-07-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Christensen SR;Kashgarian M;Alexopoulou L;Flavell RA;Akira S;Shlomchik MJ
通讯作者：
Shlomchik MJ