Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice.
Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice.
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DOI：
10.1016/j.alcohol.2020.04.003
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Sabino V
中科院分区：
文献类型：
--
作者：
Quadir SG;Rohl CD;Zeabi A;Moore CF;Cottone P;Sabino V
酒精是世界上最普遍消费和滥用的精神改变物质。存在各种动物模型来帮助我们对酒精成瘾的神经生物学理解。一个经常被认为是理所当然且没有得到一致控制的变量是啮齿动物维持的“标准”食物饮食。在这组实验中，我们试图确定不同常用饮食对酒精摄入量、乙醇偏好和机械痛敏的影响，在一种广泛使用的重度酒精饮酒模型、间歇性获得20%酒精的模型中。我们发现，服用LabDiet 5001(饮食2(LD5001))和Tekraad饮食7012(饮食3(H7012))的雄性小鼠持续喝下更多的酒精，比服用Tekraad饮食2918(饮食1(H2918))的小鼠以及服用LabDiet 5V75(饮食4(LD5V75))的小鼠喝更多的酒精。此外，与饮食1(H2918)组相比，服用LabDiet 5001(饮食2(LD5001))的小鼠的水分摄入量一直较低，偶尔服用特克拉德饮食7012(饮食3(H7012))的小鼠的水分摄入量也一直较低。我们发现，与水对照组小鼠相比，雄性小鼠在间歇性饮用酒精72小时后，在8周的间歇性饮酒后表现出强烈的机械性痛觉异常，而无论饮食，因此不同的酒精消耗量。我们的数据提供了证据，证明在所有饮酒研究中，受试者所接触的啮齿动物饮食类型是一个需要报告和控制的重要变量。
Alcohol is the most ubiquitously consumed and misused mind-altering substance in the world. Various animal models exist to aid in our neurobiological understanding of alcohol addiction. One variable too often taken for granted and not consistently controlled is the “standard” chow diet rodents are maintained on. In this set of experiments, we sought to determine the effect of different commonly used diets on ethanol intake, ethanol preference, and mechanical pain sensitivity in a widely used mouse model of heavy alcohol drinking, the intermittent access to 20% alcohol model. We found that male mice kept on LabDiet 5001 (Diet 2 (LD5001)) and on Teklad Diet 7012 (Diet 3 (H7012)) consistently drank more ethanol than mice kept on Teklad Diet 2918 (Diet 1 (H2918)) as well as compared to mice on LabDiet 5V75 (Diet 4 (LD5V75)). In addition, water intake was consistently lower in mice kept on LabDiet 5001 (Diet 2 (LD5001)), and occasionally in mice kept on Teklad Diet 7012 (Diet 3 (H7012)), compared to the Teklad Diet 2918 (Diet 1 (H2918)) group. We found that male mice showed a strong mechanical allodynia following 8 weeks of intermittent ethanol drinking at 72 hr of withdrawal, compared to water Control mice, regardless of the diet and hence of the different amount of ethanol consumed. Our data provide evidence that the type of rodent diet subject are exposed to is an important variable to report and control, in all ethanol drinking studies.
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DOI：
10.1111/acer.13252
发表时间：
2016-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Bergeson SE;Blanton H;Martinez JM;Curtis DC;Sherfey C;Seegmiller B;Marquardt PC;Groot JA;Allison CL;Bezboruah C;Guindon J
通讯作者：
Guindon J
影响因子：
6
作者：
Larson, Mary Jo;Paasche-Orlow, Michael;Samet, Jeffrey H.
通讯作者：
Samet, Jeffrey H.
DOI：
10.1523/jneurosci.4991-12.2013
发表时间：
2013-05-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Btesh J;Fischer MJM;Stott K;McNaughton PA
通讯作者：
McNaughton PA
影响因子：
3.2
作者：
Marshall, Simon Alex;Rinker, Jennifer A.;Thiele, Todd E.
通讯作者：
Thiele, Todd E.
影响因子：
2.3
作者：
FORSANDER, OA;SINCLAIR, JD
通讯作者：
SINCLAIR, JD