Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.
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DOI：
10.1155/2013/846740
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Sheu JR
中科院分区：
文献类型：
--
作者：
Jayakumar T;Hsieh CY;Lee JJ;Sheu JR
穿心莲Andrographis paniculata（Burm. F）Nees，通常被称为“苦味之王”，是一种菊科草本植物。在中国，印度，泰国和马来西亚，这种植物已被广泛用于治疗喉咙痛，流感和上呼吸道感染。穿心莲内酯是穿心莲的主要活性成分，在各种研究中显示出抗癌潜力。穿心莲及其衍生物在哮喘、中风和关节炎的实验模型中具有抗炎作用。近年来，药物化学家合成了大量穿心莲内酯衍生物，它们具有抗炎、抗菌、抗肿瘤、抗糖尿病、抗HIV、拒食和抗病毒等重要药理活性。但本文对穿心莲内酯抗心血管疾病、抗血小板活化、抗不孕、抗NF-κB活化等方面的研究进展进行了综述。因此，本文旨在提供相关文献中报道的定性研究证据，以帮助科学家分离和表征生物活性化合物。
Andrographis paniculata (Burm. F) Nees, generally known as “king of bitters,” is an herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this plant has been widely used for treating sore throat, flu, and upper respiratory tract infections. Andrographolide, a major bioactive chemical constituent of the plant, has shown anticancer potential in various investigations. Andrographolide and its derivatives have anti-inflammatory effects in experimental models asthma, stroke, and arthritis. In recent years, pharmaceutical chemists have synthesized numerous andrographolide derivatives, which exhibit essential pharmacological activities such as those that are anti-inflammatory, antibacterial, antitumor, antidiabetic, anti-HIV, antifeedant, and antiviral. However, what is noteworthy about this paper is summarizing the effects of andrographolide against cardiovascular disease, platelet activation, infertility, and NF-κB activation. Therefore, this paper is intended to provide evidence reported in relevant literature on qualitative research to assist scientists in isolating and characterizing bioactive compounds.
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影响因子：
120.7
作者：
Coresh, Josef;Selvin, Elizabeth;Levey, Andrew S.
通讯作者：
Levey, Andrew S.
DOI：
10.1136/bmj.b92
发表时间：
2009-02-16
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Briel M;Ferreira-Gonzalez I;You JJ;Karanicolas PJ;Akl EA;Wu P;Blechacz B;Bassler D;Wei X;Sharman A;Whitt I;Alves da Silva S;Khalid Z;Nordmann AJ;Zhou Q;Walter SD;Vale N;Bhatnagar N;O'Regan C;Mills EJ;Bucher HC;Montori VM;Guyatt GH
通讯作者：
Guyatt GH
影响因子：
7.9
作者：
Amroyan, E;Gabrielian, E;Wagner, H
通讯作者：
Wagner, H
DOI：
10.1164/rccm.200809-1516oc
发表时间：
2009-04-15
影响因子：
24.7
作者：
Bao, Zhang;Guan, Shouping;Wong, W. S. Fred
通讯作者：
Wong, W. S. Fred
影响因子：
4.1
作者：
Du, QZ;Jerz, G;Winterhalter, P
通讯作者：
Winterhalter, P