Gender differences in COPD: are women more susceptible to smoking effects than men?
Gender differences in COPD: are women more susceptible to smoking effects than men?
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DOI：
10.1136/thx.2009.122002
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发表时间：
2010-06
期刊：
影响因子：
10
通讯作者：
DeMeo DL
中科院分区：
文献类型：
--
作者：
Sørheim IC;Johannessen A;Gulsvik A;Bakke PS;Silverman EK;DeMeo DL
患有慢性阻塞性肺疾病（COPD）的女性吸烟者人数正在迅速增加，但是性别是否存在差异敏感性仍然存在争议。
在一项研究中，如何检查吸烟行为和随后的肺功能降低，包括954名COPD受试者和没有COPD的955名受试者。 316）和患有<20包年吸烟年份的COPD受试者（低暴露组，n = 241）。
在低暴露组中，患有COPD的女性受试者在预测的1 s（FEV1）％（48.7％vs 55.8％，p = 0.001）和更严重的疾病（50.4％vs 35.6％，p = 0.020，in in In In in 1 s（FEV1）％（48.7％），在1 s（FEV1）％中较低（p = 0.020，在1 s）黄金（慢性阻塞性肺疾病的全球倡议）第3和4阶段的妇女的受试者的FEV1％也较低（50.6％vs 56.0％，p = 0.006）和更严重的COPD（41.7％vs 31.1％的黄金阶段3和4，p = 0.050）在早期组中使用多变量回归。 0.012）在早期组中观察到类似的趋势（p = 0.057）。剂量 - 吸烟和肺部功能之间的反应关系因性别在较低的吸烟暴露水平上不同。
在患有疾病早期发作或吸烟不足的受试者中，女性与肺功能降低和更严重的疾病有关。经过考虑的。
The number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a differential susceptibility by gender remains controversial. How smoking behaviour and subsequent lung function reduction differed by gender was examined in a study including 954 subjects with COPD and 955 subjects without COPD. The study focused on two subgroups: subjects with COPD <60 years of age (early-onset group, n=316) and subjects with COPD with <20 pack-years of smoking (low exposure group, n=241). In the low exposure group, female subjects with COPD had lower forced expiratory volume in 1 s (FEV1) % predicted (48.7% vs 55.8%, p=0.001) and more severe disease (50.4% vs 35.6%, p=0.020, in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 3 and 4) than male subjects with COPD. Females also had lower FEV1% predicted (50.6% vs 56.0%, p=0.006) and more severe COPD (41.7% vs 31.1% in GOLD stage 3 and 4, p=0.050) in the early-onset group. Using multivariate regression, female gender was associated with 5.7% lower FEV1% predicted in the low exposure group (p=0.012) and a similar trend was observed in the early-onset group (p=0.057). The number of pack-years was not significantly associated with lung function in female subjects with COPD in this study, and the dose—response relationship between smoking and lung function differed by gender at lower levels of smoking exposure. Interaction analysis suggested that the effect of smoking on lung function might be different by gender (p=0.027 in all subjects with COPD). Female gender was associated with lung function reduction and more severe disease in subjects with COPD with early onset of disease or low smoking exposure. The findings may suggest a gender difference in susceptibility to the lung-damaging effects of cigarette smoking, but alternative explanations should be considered.
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围绝经期时，女性吸烟者的慢性阻塞性肺部疾病的风险增加了：一种系统的综述和荟萃分析。
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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发表时间：
2003-02-01
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
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作者：
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