Effect of catch-up growth after food restriction on the entero-insular axis in rats.
Effect of catch-up growth after food restriction on the entero-insular axis in rats.
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限食后追赶生长对大鼠肠岛轴的影响
DOI：
10.1186/1743-7075-7-45
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发表时间：
2010-05-26
影响因子：
4.5
通讯作者：
Zhang HH
中科院分区：
文献类型：
--
作者：
Chen LL;Yang WH;Zheng J;Hu X;Kong W;Zhang HH
背景限食后追赶生长(CuGFR)的特征是摄食量发生显著变化，理论上可导致GLP-1分泌的改变，从而导致胰岛功能的改变。CUGFR组大鼠禁食4周，然后分别给予0、2、4周的完全进食，而对照组大鼠则给予自由进食。测定各组大鼠OGTT时血糖、胰岛素和GLP-1水平。结果禁食4周后，CUGFR组大鼠的胰岛大小、胰岛素浓度、血浆GLP-1浓度、胰岛素浓度、绒毛高度/隐窝深度比、L细胞数均明显小于对照组，差异有统计学意义。在4周的追踪期内，胰岛素浓度和绒毛高度与隐窝深度的比率增加，并最终超过对照组的水平。但在实验结束时，胰岛大小、L细胞数、血浆GLP-1浓度和胰岛素效应均有所增加，但均未达到对照组水平。结论CUGFR降低胰岛生长素效应，部分通过降低GLP-1浓度干扰肠-岛轴，可能是CUGFR期间代谢紊乱风险增加的原因之一。
BackgroundCatch-up growth after food restriction (CUGFR) is characterized by a significant change in food intake which could theoretically lead to the change in glucagon-like peptide-1 (GLP-1) secretion that consequently results in altered functions of pancreatic islets.MethodsExperimental rats were divided into two groups. Rats in CUGFR group were put on food-restriction for 4 weeks, and then allowed full access to food for 0, 2, 4 weeks respectively while rats in the control group were offeredad libitumaccess to food. Plasma glucose, insulin and GLP-1 level during OGTT were measured in all the rats. Moreover, morphology of intestinal mucosa, number of L cells, beta cell mass, incretin effect and the expression of GLP-1 receptor (GLP-1R) gene in the islets were also determined.ResultsThe size of pancreatic islets, insulin concentration, plasma GLP-1 concentration, incretin effect, villus height-to-crypt depth ratio and L cells were all significantly decreased in CUGFR group at the end of a 4-week food-restriction period as compared with the controls. Insulin concentration and the villus height-to-crypt depth ratio were increased and finally exceeded the level of the control group over a 4-week catch-up period. Nevertheless, at the conclusion of the study, islet size, L cells number, plasma GLP-1 concentration and incretin effect increased but failed to reach the levels of the controls.ConclusionCUGFR decreases incretin effect and disturbs the entero-insular axis partially by decreasing GLP-1 concentration, which might be responsible for the increased risk of metabolic disorder during CUGFR.
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影响因子：
5.1
作者：
PRADER, A;TANNER, JM;HARNACK, GAV
通讯作者：
HARNACK, GAV
影响因子：
7.7
作者：
Jimenez-Chillaron, JC;Hernandez-Valencia, M;Patti, ME
通讯作者：
Patti, ME
DOI：
10.1152/ajpregu.00428.2002
发表时间：
2003-02-01
影响因子：
2.8
作者：
Fernández-Estívariz, C;Gu, LH;Ziegler, TR
通讯作者：
Ziegler, TR
影响因子：
6.2
作者：
GOTOH, M;MAKI, T;MONACO, AP
通讯作者：
MONACO, AP
影响因子：
8
作者：
Crowther, Nigel J.;Cameron, Noel;Gray, I. Peter
通讯作者：
Gray, I. Peter