"NETs and EETs, a Whole Web of Mess".
"NETs and EETs, a Whole Web of Mess".
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DOI：
10.3390/microorganisms8121925
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发表时间：
2020-12-04
期刊：
影响因子：
4.5
通讯作者：
Gestal MC
中科院分区：
文献类型：
--
作者：
Williams TL;Rada B;Tandon E;Gestal MC
中性粒细胞和嗜酸性粒细胞是具有非常不同功能的粒细胞。中性粒细胞是对外部威胁的第一反应者，它们使用不同的机制来控制病原体。吞噬作用、活性氧和中性粒细胞胞外陷阱 (NET) 是中性粒细胞对抗病原体的一些机制。尽管对于 NET 实际上对宿主有益还是有害存在一些争议，但这主要取决于生物学背景。 NETs 可以促进某些类型疾病的发病机制，同时它们也是不可否认的先天免疫反应的关键组成部分。相反，嗜酸性粒细胞在宿主免疫反应中的作用仍有待更好地阐明。嗜酸性粒细胞在蠕虫感染和过敏反应中发挥重要作用。嗜酸性粒细胞可以作为病毒性呼吸道感染、肠道细菌感染中的效应细胞，并通过驱动 Th1 和 Th2 反应之间的平衡作为免疫反应的调节剂。特别是，嗜酸性粒细胞的生物活性似乎与中性粒细胞的生物活性非常相似。两者都具有杀菌活性，可以激活促炎反应，可以调节适应性免疫反应，可以形成细胞外陷阱，并且根据潜在的病理学可以对宿主有益或有害。在这篇综述中，我们比较了这两种细胞类型，重点是强调它们与细胞外陷阱相关的众多相似之处。
Neutrophils and eosinophils are granulocytes that have very distinct functions. Neutrophils are first responders to external threats, and they use different mechanisms to control pathogens. Phagocytosis, reactive oxygen species, and neutrophil extracellular traps (NETs) are some of the mechanisms that neutrophils utilize to fight pathogens. Although there is some controversy as to whether NETs are in fact beneficial or detrimental to the host, it mainly depends on the biological context. NETs can contribute to disease pathogenesis in certain types of diseases, while they are also undeniably critical components of the innate immune response. On the contrary, the role of eosinophils during host immune responses remains to be better elucidated. Eosinophils play an important role during helminthic infections and allergic responses. Eosinophils can function as effector cells in viral respiratory infections, gut bacterial infections, and as modulators of immune responses by driving the balance between Th1 and Th2 responses. In particular, eosinophils have biological activities that appear to be quite similar to those of neutrophils. Both possess bactericidal activity, can activate proinflammatory responses, can modulate adaptive immune responses, can form extracellular traps, and can be beneficial or detrimental to the host according to the underlying pathology. In this review we compare these two cell types with a focus on highlighting their numerous similarities related to extracellular traps.
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影响因子：
4.6
作者：
Arcanjo A;Logullo J;Menezes CCB;de Souza Carvalho Giangiarulo TC;Dos Reis MC;de Castro GMM;da Silva Fontes Y;Todeschini AR;Freire-de-Lima L;Decoté-Ricardo D;Ferreira-Pereira A;Freire-de-Lima CG;Barroso SPC;Takiya C;Conceição-Silva F;Savino W;Morrot A
通讯作者：
Morrot A
影响因子：
38.9
作者：
Abidi, Khalid;Belayachi, Jihane;Abouqal, Redouane
通讯作者：
Abouqal, Redouane
影响因子：
5.8
作者：
Bonne-Année S;Kerepesi LA;Hess JA;Wesolowski J;Paumet F;Lok JB;Nolan TJ;Abraham D
通讯作者：
Abraham D
影响因子：
5.5
作者：
Abdala-Valencia H;Coden ME;Chiarella SE;Jacobsen EA;Bochner BS;Lee JJ;Berdnikovs S
通讯作者：
Berdnikovs S
DOI：
10.1111/j.1538-7836.2011.04544.x
发表时间：
2012-01
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Brill A;Fuchs TA;Savchenko AS;Thomas GM;Martinod K;De Meyer SF;Bhandari AA;Wagner DD
通讯作者：
Wagner DD