Majority of Chinese Medicine Herb Category "Qing Re Yao" Have Multiple Mechanisms of Anti-inflammatory Activity.
Majority of Chinese Medicine Herb Category "Qing Re Yao" Have Multiple Mechanisms of Anti-inflammatory Activity.
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DOI：
10.1038/s41598-018-25813-x
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发表时间：
2018-05-09
影响因子：
4.6
通讯作者：
Cheng YC
中科院分区：
文献类型：
--
作者：
Guan F;Lam W;Hu R;Kim YK;Han H;Cheng YC
被归类为“清热药”的草药被翻译成“清热药”，其中热症状与炎症非常相似。本研究从COX 2、iNOS活性、IL-6、IFNγ、TNF-α和糖皮质激素等6个方面对清热药中的226味中药进行了抗炎作用机制的研究，以探讨清热药是否具有抗炎作用。96%的人表现出至少一种抗炎过程或先天免疫模块活性，72%的人可以影响一种抗炎过程。其中，54种清热药中有68%影响至少两种机制，而“补益药”中只有4%（47种草药）用于“滋补身体能量”和预防疾病。43%的清热药作用于3个或3个以上的机制，而补遗药无一具有多机制作用。此外，清热药对STAT 3或GAS的活性可能对这些靶基因及其通路具有下游效应。本研究探讨了清热药治疗炎症的关键作用。这项研究还证明了分离抗炎物质的实用性，可用作药物发现和开发的先导。
Herbs categorized as “Qing Re Yao” are translated into “medicine that removes heat” where heat symptoms strongly resemble inflammation. 226 herbs, among those 54 herbs are classified as “Qing Re Yao”, were studied on six key mechanisms of inflammation: COX2, iNOS activity, and the pathways of IL-6, IFNγ, TNF-α and glucocorticoid in order to assess if the majority of this family of herbs have anti-inflammatory activity. 96% demonstrated at least one anti-inflammatory process or innate immunity modular activity, and 72% could affect one anti-inflammatory process. Of the, 54 “Qing Re Yao” 68% affect at least 2 mechanism compared to only 4% (47 herbs) in the “Bu Yi Yao” category that are used to “tonify body energy” and prevent diseases. Moreover 43% of “Qing Re Yao” herbs affect 3 or more mechanisms while none of the “Bu Yi Yao” have this poly-mechanism quality. Additionally “Qing Re Yao” herbs exhibiting activity against STAT3 or GAS could have downstream effects on these target genes and their pathways. Our study addresses the key action on why “Qing Re Yao” work on inflammation. This study also demonstrates the utility in isolating anti-inflammatory substances to be used as a lead for drug discovery and development.
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DOI：
10.1186/1476-9255-8-16
发表时间：
2011-07-07
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Lee S;Shin S;Kim H;Han S;Kim K;Kwon J;Kwak JH;Lee CK;Ha NJ;Yim D;Kim K
通讯作者：
Kim K
影响因子：
2.4
作者：
Burnett, B. P.;Jia, Q.;Levy, R. M.
通讯作者：
Levy, R. M.
影响因子：
5.6
作者：
Lun, Yuning;Xia, Hong;Lei, Linsheng
通讯作者：
Lei, Linsheng
影响因子：
3.5
作者：
Han, ZN;Boyle, DL;Firestein, GS
通讯作者：
Firestein, GS
DOI：
10.1109/access.2023.3293001
发表时间：
--
期刊：
IEEE Access
影响因子：
3.6
作者：
Yi-Ming Tseng; Bang-Ren Chen; Wei-Cheng Lin; Wen-Jay Lee; Nan-Yow Chen; Tian-Li Wu
通讯作者：
Yi-Ming Tseng