The level of maternal methemoglobin during pregnancy in an air-polluted environment.
The level of maternal methemoglobin during pregnancy in an air-polluted environment.
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DOI：
10.1289/ehp.6055
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发表时间：
2003-12
影响因子：
10.4
通讯作者：
Mohorovic L
中科院分区：
文献类型：
--
作者：
Mohorovic L
这项前瞻性研究的目的是确定在燃煤热电厂运行（“脏”期）和关闭（“干净”期）期间，孕妇体内地面二氧化硫浓度和高铁血红蛋白浓度之间是否存在相关性。在克罗地亚拉宾的普洛明1号发电厂的位置也得到了考虑。研究中每个孕妇的血液和尿液样本在清洁期（n = 138）和脏期（n = 122）分别检测三次，每次检测间隔1个月。我观察到脏期相应日期高铁血红蛋白平均值的增加与地面SO(2)浓度之间存在相关性（r = 0.72, p < 0.01）。洁净期高铁血红蛋白阴性平均值显著（r = -0.60, p <或=0.05），脏期高铁血红蛋白阳性平均值显著（r = 0.73, p 0.01）。母体高铁血红蛋白的增加可能是一种有用的生物标志物，可以确定孕妇的健康何时受到环境中有毒物质的威胁。
The objective of this prospective study was to determine if a correlation could be established between the ground-level concentrations of sulfur dioxide and methemoglobin concentrations in pregnant women when a coal-powered thermoelectric power plant was in operation ("dirty" period) and when it was closed ("clean" period). The location of the power plant, Plomin 1, in Labin, Croatia, was taken into consideration. Blood and urine samples of each pregnant woman in the study were tested three times in the clean period (n = 138) and three times in the dirty period (n = 122), with 1 month between each test. I observed a correlation between the increase in mean values of methemoglobin and the ground-level concentration of SO(2) on corresponding dates during the dirty period (r = 0.72, p < 0.01). In the clean period, the negative mean value of methemoglobin was significant (r = -0.60, p <or=0.05), whereas in the dirty period, the positive mean value of methemoglobin was significant (r = 0.73, p 0.01). The increase of maternal methemoglobin could be a useful biomarker to determine when the health of pregnant women is threatened by toxic substances in the environment.
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DOI：
10.1016/s0002-9378(97)70572-6
发表时间：
1997-03-01
影响因子：
9.8
作者：
Jaffe, R;Jauniaux, E;Hustin, J
通讯作者：
Hustin, J
DOI：
10.1016/s1297-9589(01)00177-1
发表时间：
2001-07-01
期刊：
Gynecologie, obstetrique & fertilite
影响因子：
--
作者：
Ferre, F
通讯作者：
Ferre, F
影响因子：
4.8
作者：
Walsh, SW;Vaughan, JE;Roberts, LJ
通讯作者：
Roberts, LJ
DOI：
10.1016/0028-2243(91)90120-a
发表时间：
1991-07-25
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
DEKKER, GA;KRAAYENBRINK, AA;VANKAMP, GJ
通讯作者：
VANKAMP, GJ
影响因子：
6.6
作者：
Jenkins, Carol;Wilson, Rhoda;Walker, James J.
通讯作者：
Walker, James J.