Indiscriminate amygdala response to mothers and strangers after early maternal deprivation.
Indiscriminate amygdala response to mothers and strangers after early maternal deprivation.
复制标题
早期孕产妇剥夺后，杏仁核对母亲和陌生人的反应不加区分。
DOI：
10.1016/j.biopsych.2013.05.025
复制
发表时间：
2013-12-01
影响因子：
10.6
通讯作者：
Tottenham, Nim
中科院分区：
文献类型：
--
作者：
Olsavsky, Aviva K.;Telzer, Eva H.;Shapiro, Mor;Humphreys, Kathryn L.;Flannery, Jessica;Goff, Bonnie;Tottenham, Nim
关键词：
在高级物种中，母体刺激对杏仁核的发育和依恋相关行为具有强大的影响。在人类中，母性剥夺与对非生育成年人的“不分青红皂白的友好”和杏仁核发育的改变有关。我们假设，母亲的剥夺将与减少杏仁核之间的母亲和陌生人的歧视和增加父母的报告不分青红皂白的友好行为。67名青少年[33名先前被收容（PI）; 34名比较（Comp）;年龄在4-17岁]参加了一项fMRI实验，旨在检查杏仁核对母亲和陌生人面孔的反应。测量扫描仪内行为。不分青红皂白的友好使用父母的报告进行评估。比较青年表现出杏仁核的反应，明确区分母亲与陌生人的刺激。相反，PI青少年表现出减少杏仁核之间的母亲和陌生人的歧视。杏仁核分化的减少与更多的不分青红皂白的友好报告有关。这些影响与收养年龄有关，后来的收养与杏仁核歧视减少和更多的不分青红皂白的友好有关。我们的研究结果表明，早期的母亲剥夺与减少杏仁核之间的母亲和陌生人的歧视，减少杏仁核的歧视与更多的报告不分青红皂白的友好。此外，这些影响随着收养年龄的增加而增加。这些数据表明，杏仁核，在某种程度上，与不分青红皂白的友好，并可能有一个机构养育和不分青红皂白的友好之间的剂量反应关系。
In altricial species, maternal stimuli have powerful effects on amygdala development and attachment-related behaviors. In humans, maternal deprivation has been associated with both “indiscriminate friendliness” towards non-caregiving adults and altered amygdala development. We hypothesized that maternal deprivation would be associated with reduced amygdala discrimination between mothers and strangers and increased parent report of indiscriminate friendliness behaviors. 67 youths [33 previously-institutionalized (PI); 34 Comparison (Comp); age-at-scan 4-17 y] participated in an fMRI experiment designed to examine amygdala response to mother versus stranger faces. In-scanner behavior was measured. Indiscriminate friendliness was assessed using parental report. Comparison youth showed an amygdala response that clearly discriminated mother versus stranger stimuli. PI youths, by contrast, exhibited reduced amygdala discrimination between mothers and strangers. Reduced amygdala differentiation correlated with greater reports of indiscriminate friendliness. These effects correlated with age-at-adoption, with later adoptions being associated with reduced amygdala discrimination and more indiscriminate friendliness. Our results suggest that early maternal deprivation is associated with reduced amygdala discrimination between mothers and strangers, and reduced amygdala discrimination was associated with greater reports of indiscriminate friendliness. Moreover, these effects increased with age-at-adoption. These data suggest that the amygdala, in part, is associated with indiscriminate friendliness, and that there may be a dose-response relationship between institutional rearing and indiscriminate friendliness.
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DOI：
10.1111/j.1749-6632.2010.05445.x
发表时间：
2010-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2010
影响因子：
--
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
1.3
作者：
Achenbach, T M;Ruffle, T M
通讯作者：
Ruffle, T M
DOI：
10.1037/h0020970
发表时间：
1965-01-01
期刊：
JOURNAL OF CONSULTING PSYCHOLOGY
影响因子：
--
作者：
CLEMENTS, GR
通讯作者：
CLEMENTS, GR
DOI：
10.1111/j.1469-7610.1989.tb00770.x
发表时间：
1989-01-01
影响因子：
7.6
作者：
HODGES, J;TIZARD, B
通讯作者：
TIZARD, B
DOI：
10.1016/j.jaac.2010.12.012
发表时间：
2011-03-01
影响因子：
13.3
作者：
Gleason, Mary Margaret;Fox, Nathan A.;Zeanah, Charles H.
通讯作者：
Zeanah, Charles H.