Balancing ER dynamics: shaping, bending, severing, and mending membranes.

Balancing ER dynamics: shaping, bending, severing, and mending membranes.
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DOI:
10.1016/j.ceb.2011.04.007
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发表时间:
2011-08
影响因子:
7.5
通讯作者:
Daga, Andrea
Daga, Andrea
中科院分区:
生物学2区
文献类型:
--
作者:
Pendin, Diana;McNew, James A.;Daga, Andrea

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内质网是一种多功能细胞器,由功能和形态上不同的域组成。这些包括相对平坦的核膜和外周内质网,这是一个与遍布整个细胞质的小管互连的片状池网络。 ER 是高度动态的,其结构域的形状及其相对内容不断变化。驱动这些形态变化的多种力量取决于内质网和微管之间的相互作用、膜融合和裂变事件以及能够主动塑造膜的蛋白质的作用。这些力之间的相互作用最终决定了内质网的动态形态,而这反过来又对于正确执行该细胞器的各种功能至关重要。
The endoplasmic reticulum is a multifunctional organelle composed of functionally and morphologically distinct domains. These include the relatively planar nuclear envelope and the peripheral ER, a network of sheet-like cisternae interconnected with tubules that spread throughout the cytoplasm. The ER is highly dynamic and the shape of its domains as well as their relative content are in constant flux. The multiple forces driving these morphological changes depend on the interaction between the ER and microtubules, membrane fusion and fission events and the action of proteins capable of actively shaping membranes. The interplay between these forces is ultimately responsible for the dynamic morphology of the ER, which in turn is crucial for properly executing the varied functions of this organelle.
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