Design of a drug discovery course for non-science majors.
Design of a drug discovery course for non-science majors.
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DOI：
10.1002/bmb.21121
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Dube DH
中科院分区：
文献类型：
--
作者：
Dube DH
“药物发现”是一门为期13周的讲座和实验室课程，旨在向非理科专业的学生介绍基础化学和生物化学概念，因为它们与药物发现的统一主题有关。这门课程的第一部分致力于培养学生对分子的理解，了解它们的性质，了解使它们相互分离的差异，以及它们与生物受体结合并引发生理效应的能力。在建立了学生的分子世界观之后，这门课程将重点放在四类药物上：抗菌剂、影响大脑的药物、类固醇类药物和抗癌药物。在每个模块中，重点是了解疾病的基础和分子水平的相互作用如何使我们能够识别新的药物化合物。定期的课堂讨论基于与课堂主题相关的文章，从抗生素耐药性的S，到成瘾的分子基础，再到合理的药物设计，使学生能够将课程材料与国家和日常关注的紧迫问题联系起来。除了上课时间外，每周以探究为基础的实验室允许学生批判性地分析与课程概念相关的数据，并在本学期晚些时候为学生提供机会设计和实施他们自己的实验来筛选抗微生物活性。这门课程让学生了解化学和生物化学对人类健康的重要性，同时强调与药物发现相关的过程、策略和挑战。
“Drug Discovery” is a 13-week lecture and laboratory-based course that was developed to introduce non-science majors to foundational chemistry and biochemistry concepts as they relate to the unifying theme of drug discovery. The first part of this course strives to build students’ understanding of molecules, their properties, the differences that enable them to be separated from one another, and their abilities to bind to biological receptors and elicit physiological effects. After building students’ molecular worldview, the course then focuses on four classes of drugs: antimicrobials, drugs that affect the mind, steroid-based drugs, and anti-cancer drugs. During each of these modules, an emphasis is placed on how understanding the basis of disease and molecular-level interactions empowers us to identify novel medicinal compounds. Periodic in class discussions based on articles pertinent to class topics ranging from the s of antibiotic resistance, to the molecular basis of addiction, to rational drug design, are held to enable students to relate course material to pressing problems of national and daily concern. In addition to class time, weekly inquiry-based laboratories allow students to critically analyze data related to course concepts, and later in the semester give students an opportunity to design and implement their own experiments to screen for antimicrobial activity. This course provides students with an understanding of the importance of chemistry and biochemistry to human health while emphasizing the process, strategies, and challenges related to drug discovery.
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