Two New Phenylhydrazone Derivatives from the Pearl River Estuary Sediment-Derived Streptomyces sp. SCSIO 40020.
Two New Phenylhydrazone Derivatives from the Pearl River Estuary Sediment-Derived Streptomyces sp. SCSIO 40020.
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两种新的苯腙衍生物来自珠江口沉积物来源的链霉菌。
作者：
从采自珠江口沉积物的链霉菌SCSIO 40020中分离得到两个新的苯腙类衍生物和一个新的生物碱，分别为喷佐霉素A-B（1-2）和去甲霉素A（3），以及三个已知化合物，包括一个生物碱（4）和两个倍半萜类化合物（5-6）。通过1D/2D NMR、质谱和X-射线晶体学对其结构和绝对构型进行了归属。通过SRB方法在四种人癌细胞系中评价化合物1，并且在三种癌细胞系中显示出弱的细胞毒性，IC 50值在30.44至61.92 μM的范围内，其与阳性对照顺铂的那些相当。生物信息学分析的推定的生物合成基因簇表明，参与1和2的腙形成的Japp-Klingemann偶联反应。
Two new phenylhydrazone derivatives and one new alkaloid, penzonemycins A–B (1–2) and demethylmycemycin A (3), together with three known compounds including an alkaloid (4) and two sesquiterpenoids (5–6), were isolated from the Streptomyces sp. SCSIO 40020 obtained from the Pearl River Estuary sediment. Their structures and absolute configurations were assigned by 1D/2D NMR, mass spectroscopy and X-ray crystallography. Compound 1 was evaluated in four human cancer cell lines by the SRB method and displayed weak cytotoxicity in three cancer cell lines, with IC50 values that ranged from 30.44 to 61.92 µM, which were comparable to those of the positive control cisplatin. Bioinformatic analysis of the putative biosynthetic gene cluster indicated a Japp–Klingemann coupling reaction involved in the hydrazone formation of 1 and 2.
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