Key Knowledge Gaps for Plasmodium vivax Control and Elimination.

Key Knowledge Gaps for Plasmodium vivax Control and Elimination.
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DOI:
10.4269/ajtmh.16-0180
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发表时间:
2016-12-28
期刊:
The American journal of tropical medicine and hygiene
影响因子:
--
通讯作者:
Baird JK
Baird JK
中科院分区:
其他
文献类型:
--
作者:
Bassat Q;Velarde M;Mueller I;Lin J;Leslie T;Wongsrichanalai C;Baird JK

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间日疟原虫是地理上最广泛的人类疟疾病因,但对间日疟原虫的生物学、病理学、传播和控制认识不足。在过去的几十年里,对这个物种的研究被忽视了,部分原因是人们错误地认为它本质上是良性的。此外,培养寄生虫的许多技术挑战也阻碍了对其基本生物学和对化疗的分子和细胞反应的了解。在今后十年,需要大力扩大对间日疟疾的研究,以加速消除和根除间日疟疾。本文总结了由世界卫生组织召集的研究人员、国家疟疾控制规划和其他利益相关者确定的关键知识差距,以制定控制和消除间日疟疾的战略。本文中提出的优先级是在这些技术讨论中出现的,并被作者的专家共识所采用。所有参与者都明白,在这项研究议程中,实用主义是优先考虑的事项,即专注于提供更好的间日疟原虫预防、诊断、治疗和监测工具。
There is inadequate understanding of the biology, pathology, transmission, and control of Plasmodium vivax, the geographically most widespread cause of human malaria. During the last decades, study of this species was neglected, in part due to the erroneous belief that it is intrinsically benign. In addition, many technical challenges in culturing the parasite also hampered understanding its fundamental biology and molecular and cellular responses to chemotherapeutics. Research on vivax malaria needs to be substantially expanded over the next decade to accelerate its elimination and eradication. This article summarizes key knowledge gaps identified by researchers, national malaria control programs, and other stakeholders assembled by the World Health Organization to develop strategies for controlling and eliminating vivax malaria. The priorities presented in this article emerged in these technical discussions, and were adopted by expert consensus of the authors. All involved understood the priority placed upon pragmatism in this research agenda, that is, focus upon tools delivering better prevention, diagnosis, treatment, and surveillance of P. vivax.
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