Bone metabolism of milk goats and sheep during second pregnancy and lactation in comparison to first lactation.
Bone metabolism of milk goats and sheep during second pregnancy and lactation in comparison to first lactation.
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与第一次哺乳期相比，第二次妊娠和哺乳期奶山羊和绵羊的骨代谢。
DOI：
10.1111/j.1439-0396.2007.00695.x
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发表时间：
2007
影响因子：
2.7
通讯作者：
Marcel Wanner
中科院分区：
文献类型：
--
作者：
Annette Liesegang;Juha Risteli;Marcel Wanner
在妊娠后期和哺乳期，骨骼组织大量丢失。本研究的目的是跟踪妊娠和哺乳期山羊和绵羊的这些变化，比较这两个物种在第二次哺乳期间的情况，并将结果与第一次哺乳进行比较。在妊娠期每月、产后2或3天（pp）、pp 2周、pp 4周和哺乳期每月采集12只成年奶山羊（萨宁山羊）和绵羊（Ostfriesen奶绵羊）的血液样品，直至产后7个月。采用外周定量计算机断层扫描（pQCT），以与采血相同的时间间隔对总骨矿物质含量（BMC）和总骨矿物质密度（BMD）进行定量。使用I型胶原羧基末端肽的两个不同结构域（ICTP和crosslaps）在血清中评估骨吸收。用骨钙素（OC）和骨特异性碱性磷酸酶（bAP）在血清中定量骨形成。此外，还测定了血清中的Ca和1，25二羟基维生素D（VITD）。在第一次和第二次妊娠和哺乳期间进行相同的程序。两种动物种属的平均ICTP和crosslaps浓度在妊娠的最后一个月显示增加。与此相反，平均OC浓度下降缓慢，从第2个月的怀孕，直到第一周PP。平均bAP活性也显示出类似的时间过程。两个物种的总BMC和BMD下降，直到第一周pp。之后，BMC在哺乳期再次增加。绵羊和山羊的BMD水平在哺乳期恢复到正常水平。维生素D浓度在第一周达到峰值。只有VITD浓度在山羊保持升高相比，在整个哺乳期的第二次泌乳期间的泌乳值。分娩前后和哺乳期开始时，骨重建的骨吸收阶段加速，但与骨形成过程脱钩。这些哺乳动物骨中矿物质的减少似乎是可逆的。因为在哺乳期间，骨重建具有骨吸收和骨形成阶段紧密耦合。有趣的是，在这些物种中，在第二次妊娠和哺乳期用BMC和BMD测量的骨丢失不像第一次哺乳期那样突出，但显示出几乎相同的过程，尽管动物在第二次哺乳期提供更多的牛奶。这两个物种的第二次泌乳似乎比第一次泌乳更容易适应环境。
Substantial losses of skeletal tissue occur during late pregnancy and lactation. The goal of the present study was to follow these changes in pregnant and lactating goats and sheep, compare these two species during their second lactation, and also compare the results to the first lactation. Blood samples were collected from 12 adult dairy goats (Saanen goat) and sheep (Ostfriesen milk sheep) monthly during gestation, 2 or 3 days postpartum (pp), 2 weeks pp, 4 weeks pp, and then monthly during lactation until 7 months after parturition. Total bone mineral content (BMC) and total bone mineral density (BMD) were quantified using peripheral quantitative computed tomography (pQCT) at the same intervals as the blood was taken. Bone resorption was assessed in serum using two different domains of the carboxyterminal telopeptide of type I collagen (ICTP and crosslaps). Bone formation was quantified in serum with osteocalcin (OC) and bone-specific alkaline phosphatase (bAP). In addition, Ca and 1,25 dihydroxy vitamin D (VITD) were determined in serum. The same procedure was done during the first and second gestation and lactation. Mean ICTP and crosslaps concentrations of the two animal species showed an increase in the last month of gestation. In contrast, mean OC concentrations decreased slowly from the 2nd month of pregnancy until the first week pp. Also mean bAP activities showed a similar time course. Total BMC and BMD decreased until the first week pp in both species. Afterwards, BMC increased again during lactation. BMD levels of sheep and goats returned to prepartum levels during lactation. Vitamin D concentrations peaked in the first week pp. Only VITD concentrations in goats stayed elevated compared with prepartum values throughout the whole lactation during the second lactation. Around parturition and at the beginning of lactation, the bone resorptive phase of bone remodelling is accelerated, but is uncoupled from the process of bone formation. The mineral decrease in bone of these lactating animals seems to be reversible. Since during lactation, bone remodelling has bone resorption and formation phases tightly coupled. Interestingly, in these species, the bone loss in the second pregnancy and lactation measured with BMC and BMD is not as prominent as in the first lactation, but shows almost the same course, although the animals gave more milk in the second lactation. It seems that the organism adapts to the circumstances more easily in the second lactation compared to the first lactation in these two species.
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影响因子：
4.1
作者：
Miller,MA;Omura,TH;Miller,SC
通讯作者：
Miller,SC
影响因子：
20.3
作者：
C. Kovacs;H. Kronenberg
通讯作者：
C. Kovacs;H. Kronenberg
食蟹猴妊娠期和哺乳期骨量和骨生物标志物的变化。
DOI：
10.1210/jcem.83.12.5344
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Lees,CJ;Jerome,CP;Register,TC;Carlson,CS
通讯作者：
Carlson,CS
影响因子：
4.1
作者：
Turner,CH;Chandran,A;Pidaparti,RM
通讯作者：
Pidaparti,RM
影响因子：
3.6
作者：
Vajda,EG;Kneissel,M;Muggenburg,B;Miller,SC
通讯作者：
Miller,SC