Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.
复制标题
DOI：
10.1016/j.biomaterials.2021.121114
复制
发表时间：
2021-10
期刊：
影响因子：
14
通讯作者：
Varghese S
中科院分区：
文献类型：
--
作者：
Newman H;Shih YV;Varghese S
损伤后5-10%的病例发生骨愈合受损，导致重大的经济和临床影响。虽然损伤后的炎症反应对于促进愈合是必要的，但其解决对于骨组织修复至关重要，因为在患者和动物模型中，急性或慢性炎症升高与愈合受损有关。这一过程是由免疫细胞之间的重要串扰控制的，通过介质有助于局部愈合环境中炎症的解决。调节初始炎症阶段的方法，随后其消退，导致骨再生的促再生环境。在这篇综述中，我们讨论了炎症在骨修复中的作用，炎症失调对骨组织再生的负面影响，以及如何及时解决炎症是实现正常愈合的必要条件。我们将讨论生物材料在治疗大骨缺损中的应用，特别关注骨损伤后炎症的解决，以调节免疫环境，以及它们观察到的功能益处。我们通过讨论可能导致实现骨组织修复的抗炎治疗的未来策略来结束综述。
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant economic and clinical impact. While an inflammatory response upon injury is necessary to facilitate healing, its resolution is critical for bone tissue repair as elevated acute or chronic inflammation is associated with impaired healing in patients and animal models. This process is governed by important crosstalk between immune cells through mediators that contribute to resolution of inflammation in the local healing environment. Approaches modulating the initial inflammatory phase followed by its resolution leads to a pro-regenerative environment for bone regeneration. In this review, we discuss the role of inflammation in bone repair, the negative impact of dysregulated inflammation on bone tissue regeneration, and how timely resolution of inflammation is necessary to achieve normal healing. We will discuss applications of biomaterials to treat large bone defects with a specific focus on resolution of inflammation to modulate the immune environment following bone injury, and their observed functional benefits. We conclude the review by discussing future strategies that could lead to the realization of anti-inflammatory therapeutics for bone tissue repair.
登录
查看更多内容
影响因子：
29
作者：
Baker RG;Hayden MS;Ghosh S
通讯作者：
Ghosh S
影响因子：
--
作者：
Abdul Ameer, Lubaba A;Raheem, Zainab J;Khairi, Azza Wala Aldeen
通讯作者：
Khairi, Azza Wala Aldeen
影响因子：
4.2
作者：
Behrends, D. A.;Hui, D.;Martineau, P. A.
通讯作者：
Martineau, P. A.
专门的促解决介质：感染和炎症的内源性调节剂。
DOI：
10.1038/nri.2015.4
发表时间：
2016-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Basil MC;Levy BD
通讯作者：
Levy BD
影响因子：
7.4
作者：
Andorko JI;Jewell CM
通讯作者：
Jewell CM