Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine.
Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine.
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DOI：
10.1002/btm2.10063
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发表时间：
2017-06
影响因子：
7.4
通讯作者：
Jewell CM
中科院分区：
文献类型：
--
作者：
Andorko JI;Jewell CM
疫苗和免疫治疗领域的最新研究表明，即使在没有其他免疫刺激信号的情况下，生物材料也能够激活免疫途径。有趣的是，新的研究表明，这些反应受到材料的物理化学性质的影响。几乎所有这些工作都是在疫苗和免疫治疗领域完成的，但将同样的知识应用于组织工程和再生医学有巨大的机会。这篇综述讨论了最近的发现，揭示了材料属性-尺寸、形状、化学功能-如何影响免疫反应，并将这些变化与组织工程和再生医学中出现的机会联系起来。我们首先讨论从疫苗和免疫疗法的背景下进行的研究中学到了什么。其次，重点研究了使包括巨噬细胞和树突状细胞在内的固有免疫细胞偏向炎症或伤口愈合表型的材料的特性。我们还讨论了最近的研究表明，在组织工程应用中使用的支架可以影响适应性免疫系统的细胞-B和T细胞淋巴细胞-以促进再生组织微环境。通过更深入地研究可植入材料和支架的固有免疫原性，将出现新的翻译机会，以更好地控制组织工程和再生医学的应用。
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune‐stimulating signals. Intriguingly, new studies reveal these responses are influenced by the physicochemical properties of the material. Nearly all of this work has been done in the vaccine and immunotherapy fields, but there is tremendous opportunity to apply this same knowledge to tissue engineering and regenerative medicine. This review discusses recent findings that reveal how material properties—size, shape, chemical functionality—impact immune response, and links these changes to emerging opportunities in tissue engineering and regenerative medicine. We begin by discussing what has been learned from studies conducted in the contexts of vaccines and immunotherapies. Next, research is highlighted that elucidates the properties of materials that polarize innate immune cells, including macrophages and dendritic cells, toward either inflammatory or wound healing phenotypes. We also discuss recent studies demonstrating that scaffolds used in tissue engineering applications can influence cells of the adaptive immune system—B and T cell lymphocytes—to promote regenerative tissue microenvironments. Through greater study of the intrinsic immunogenic features of implantable materials and scaffolds, new translational opportunities will arise to better control tissue engineering and regenerative medicine applications.
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影响因子：
9.7
作者：
Andorko JI;Hess KL;Pineault KG;Jewell CM
通讯作者：
Jewell CM
影响因子：
4.9
作者：
Andorko, James I.;Pineault, Kevin G.;Jewell, Christopher M.
通讯作者：
Jewell, Christopher M.
影响因子：
10
作者：
Christo, Susan N.;Bachhuka, Akash;Vasilev, Krasimir
通讯作者：
Vasilev, Krasimir
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
17.1
作者：
Bartneck, Matthias;Keul, Heidrun A.;Groll, Juergen
通讯作者：
Groll, Juergen