Electrochemical immunosensors for detection of cancer protein biomarkers.
Electrochemical immunosensors for detection of cancer protein biomarkers.
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DOI：
10.1021/nn3023969
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发表时间：
2012-08-28
期刊：
影响因子：
17.1
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Chikkaveeraiah, Bhaskara V.;Bhirde, Ashwinkumar A.;Morgan, Nicole Y.;Eden, Henry S.;Chen, Xiaoyuan
Bioanalytical methods have experienced unprecedented growth in recent years, driven in large part by the need for faster, more sensitive, more portable (“point of care”) systems to detect protein biomarkers for clinical diagnosis. Electrochemical detection strategies, used in conjunction with immunosensors, offer advantages, because they are fast, simple, and low cost. Recent developments in electrochemical immunosensors have significantly improved the sensitivity needed to detect low concentrations of biomarkers present in early stages of cancer. Moreover, the coupling of electrochemical devices with nanomaterials, such as gold nanoparticles, carbon nanotubes, magnetic particles, and quantum dots, offers multiplexing capability for simultaneous measurements of multiple cancer biomarkers. This review will discuss recent advances in the development of electrochemical immunosensors for the next-generation of cancer diagnostics, with an emphasis on opportunities for further improvement in cancer diagnostics and treatment monitoring. Details will be given for strategies to increase sensitivity through multi-label amplification, coupled with high densities of capture molecules on sensor surfaces. Such sensors are capable of detecting a wide range of protein quantities, from ng to fg (depending on the protein biomarkers of interest), in a single sample.
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影响因子：
12.6
作者：
Chikkaveeraiah, Bhaskara V.;Mani, Vigneshwaran;Patel, Vyomesh;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
用于生物标志物多重测量和即时检测的三维纸基电化学发光免疫装置
影响因子：
14
作者：
Ge, Lei;Yan, Jixian;Yu, Jinghua
通讯作者：
Yu, Jinghua
DOI：
10.3390/s100100428
发表时间：
2010
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Choi YE;Kwak JW;Park JW
通讯作者：
Park JW
影响因子：
--
作者：
Bensmail H;Haoudi A
通讯作者：
Haoudi A
影响因子：
7.4
作者：
Centi, Sonia;Tombelli, Sara;Mascini, Marco
通讯作者：
Mascini, Marco