Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections.
Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections.
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DOI：
10.3390/ijms22020482
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发表时间：
2021-01-06
影响因子：
5.6
通讯作者：
Esin S
中科院分区：
文献类型：
--
作者：
Batoni G;Maisetta G;Esin S
人们普遍认为，许多人体慢性感染具有多微生物病因学。这些包括糖尿病足溃疡感染、囊性纤维化患者的肺部感染、牙周炎、中耳炎、尿路感染甚至一部分全身性感染。混合感染的治疗给临床带来了严峻的挑战。首先，微生物的多微生物群落经常将自己组织成生物膜，这些生物膜对抗微生物治疗和宿主免疫系统的清除是出了名的顽固。其次，群落成员之间过多的相互作用可能影响毒力因子的表达和群落中单个物种对抗菌素的易感性。因此，迫切需要制定和评估能够针对混合种群中多种病原体的新策略。在这方面，抗菌或宿主防御肽（amp）值得特别关注，因为它们具有许多可能有助于这一目的的有利特征。本综述的目的是提供一个全面和最新的研究概述，解决抗菌肽在混合感染中的治疗潜力，突出这类抗菌药物在对抗多微生物感染方面提供的机会，但也可能出现在这类应用中的限制。
It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infections poses serious challenges in the clinic. First, polymicrobial communities of microorganisms often organize themselves as biofilms that are notoriously recalcitrant to antimicrobial therapy and clearance by the host immune system. Secondly, a plethora of interactions among community members may affect the expression of virulence factors and the susceptibility to antimicrobials of individual species in the community. Therefore, new strategies able to target multiple pathogens in mixed populations need to be urgently developed and evaluated. In this regard, antimicrobial or host defense peptides (AMPs) deserve particular attention as they are endowed with many favorable features that may serve to this end. The aim of the present review is to offer a comprehensive and updated overview of studies addressing the therapeutic potential of AMPs in mixed infections, highlighting the opportunities offered by this class of antimicrobials in the fight against polymicrobial infections, but also the limits that may arise in their use for this type of application.
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