Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts.
Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts.
复制标题
皮质集合管表皮生长因子抑制钠转运的机制。
DOI：
10.1152/ajprenal.1991.261.5.f896
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Hamm,LL
中科院分区：
文献类型：
--
作者：
Vehaskari,VM;Herndon,J;Hamm,LL
Epidermal growth factor (EGF) inhibits Na transport in the cortical collecting ducts (CCD). To gain insight into the signal transduction of this effect, several potential mechanisms were examined in rabbit CCD perfused in vitro. Pretreatment with pertussis toxin, indomethacin, or the protein kinase C inhibitor H7 did not prevent the acute 34-50% decrease in lumen-to-bath 22Na flux (JNa) on exposure to peritubular EGF, indicating that the inhibition is not mediated by a Gi protein, prostaglandin E2 (PGE2), or protein kinase C. Inhibition of the basolateral Na-H exchanger was also without an effect. Lowering the bath Ca concentration from 1.2 to 0.11 mM did not prevent the inhibition of JNa by EGF (JNa decreased significantly by 38.7 +/- 6.9% and 29.1 +/- 5.3%, respectively); in contrast, reduction of the bath free Ca to 0.005 mM totally abolished the effect of EGF. The response to EGF was also assessed in the setting of chronic stimulation of Na transport; inhibition of JNa by EGF was still observed in CCD from remnant kidneys and in CCD from mineralocorticoid-treated rabbits. The results demonstrate that the inhibition of CCD Na transport by EGF is dependent on peritubular Ca. This suggests that the signal transduction involves Ca influx across the basolateral membrane and that increased cytosolic free Ca may be a common pathway for the counterregulatory control of Na reabsorption by several agonists.
登录
查看更多内容
Friend 鼠白血病病毒对自然杀伤细胞活性的抑制。
DOI：
10.1093/jnci/72.6.1349
发表时间：
1984
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
D. Moody;S. Specter;M. Bendinelli;H. Friedman
通讯作者：
H. Friedman
影响因子：
4.4
作者：
K. Kuribayashi;S. Gillis;D. Kern;C. Henney
通讯作者：
K. Kuribayashi;S. Gillis;D. Kern;C. Henney
细菌脂多糖和天然大麻素的致命相互作用。
DOI：
--
发表时间：
1978
期刊：
Journal of the Reticuloendothelial Society
影响因子：
--
作者：
A. Munson;V. M. Sanders;S. Bradley;S. Loveless;L. Harris
通讯作者：
L. Harris
大麻素对宿主对单核细胞增生李斯特菌和单纯疱疹病毒抵抗力的影响
影响因子：
3.1
作者：
P. Morahan;P. Klykken;S. Smith;L. Harris;A. Munson
通讯作者：
A. Munson
单细胞水平上细胞介导的细胞毒性机制。
影响因子：
4.4
作者：
E. A. Grimm;B. Bonavida
通讯作者：
B. Bonavida