The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing.
The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing.
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α-和β-微管蛋白蛋白的丧失是长期饮酒和自然脑衰老的病理标志。
DOI：
10.3390/brainsci8090175
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发表时间：
2018-09-11
期刊：
影响因子：
3.3
通讯作者：
Carter WG
中科院分区：
文献类型：
--
作者：
Labisso WL;Raulin AC;Nwidu LL;Kocon A;Wayne D;Erdozain AM;Morentin B;Schwendener D;Allen G;Enticott J;Gerdes HK;Johnson L;Grzeskowiak J;Drizou F;Tarbox R;Osna NA;Kharbanda KK;Callado LF;Carter WG
Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals were divided into equal groups of 11 control, 11 alcoholic, 11 non-alcoholic suicides, and 11 suicide alcoholics matched for age, sex, and post-mortem delay. Tissue from alcoholic cohorts displayed significantly reduced expression of α- and β-tubulins, and increased levels of acetylated α-tubulin. Protein levels of histone deacetylase-6 (HDAC6), and the microtubule-associated proteins MAP-2 and MAP-tau were reduced in alcoholic cohorts, although for MAPs this was not significant. Tubulin gene expressions increased in alcoholic cohorts but not significantly. Brains from rats administered alcohol for 4 weeks also displayed significantly reduced tubulin protein levels and increased α-tubulin acetylation. PFC tissue from control subjects had reduced tubulin protein expression that was most notable from the sixth to the eighth decade of life. Collectively, loss of neuronal tubulin proteins are a hallmark of both chronic alcohol consumption and natural brain ageing. The reduction of cytosolic tubulin proteins could contribute to the brain volumetric losses reported for alcoholic patients and the elderly.
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DOI：
10.1007/978-1-4419-6787-9_29
发表时间：
2011-01-01
期刊：
CYTOSKELETON OF THE NERVOUS SYSTEM
影响因子：
--
作者：
Evrard, Sergio G.;Brusco, Alicia
通讯作者：
Brusco, Alicia
影响因子：
2.8
作者：
HARPER, CG;KRIL, JJ
通讯作者：
KRIL, JJ
影响因子：
64.8
作者：
Hubbert, C;Guardiola, A;Yao, TP
通讯作者：
Yao, TP
影响因子：
5.7
作者：
Giorgio, Antonio;Santelli, Luca;Tomassini, Valentina;Bosnell, Rose;Smith, Steve;De Stefano, Nicola;Johansen-Berg, Heidi
通讯作者：
Johansen-Berg, Heidi
影响因子：
3.4
作者：
Durazzo TC;Mon A;Gazdzinski S;Yeh PH;Meyerhoff DJ
通讯作者：
Meyerhoff DJ