Serial longitudinal magnetic resonance imaging data indicate non-linear regional gray matter volume recovery in abstinent alcohol-dependent individuals.
Serial longitudinal magnetic resonance imaging data indicate non-linear regional gray matter volume recovery in abstinent alcohol-dependent individuals.
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DOI：
10.1111/adb.12180
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发表时间：
2015-09
影响因子：
3.4
通讯作者：
Meyerhoff DJ
中科院分区：
文献类型：
--
作者：
Durazzo TC;Mon A;Gazdzinski S;Yeh PH;Meyerhoff DJ
从酒精使用障碍中恢复的患者在持续戒酒的第一年中区域体积变化的轨迹尚不清楚，因为以前的研究通常只采用两个评估点。为了更好地了解寻求治疗的酒精依赖个体（ALC）局部脑容量恢复的轨迹，在持续戒酒1周、1个月和7.5个月后，通过1.5特斯拉的磁共振成像测量局部脑容量。ALC显示在7.5个月的戒断期间，额叶、顶叶和枕叶灰质（GM）和白色物质（WM）、总皮质GM和总脑叶WM、丘脑和小脑的体积显著增加，脑室体积减少。在区域GM的体积增加显着大于1周至1个月，从1个月到7.5个月的禁欲，表明在区域GM的非线性变化率超过7.5个月。总体而言，区域性脑叶WM在7.5个月内呈线性体积增加。随着年龄的增长，吸烟ALC表现出较低的额叶和总皮质GM体积恢复比非吸烟ALC。尽管显着的体积增加，ALC显示较小的GM体积在所有地区，除了额叶皮层，比对照组后7.5个月的禁欲。ALC和对照组在任何评估点均未显示区域WM体积差异。仅在非吸烟ALC中，增加区域GM和WM体积与提高加工速度有关。研究结果可能表明，在早期戒断期间，有助于GM和WM体积的细胞类型/细胞组分的恢复率不同，并且在该ALC队列中，GM体积不足在持续清醒7.5个月后持续存在。
The trajectory of regional volume changes during the first year of sustained abstinence in those recovering from an alcohol use disorder is unclear because previous research typically employed only two assessment points. To better understand the trajectory of regional brain volume recovery in treatment-seeking alcohol dependent individuals (ALC), regional brain volumes were measured after 1-week, 1-month, and 7.5-months of sustained abstinence, via magnetic resonance imaging at 1.5 Tesla. ALC showed significant volume increases in frontal, parietal, and occipital gray matter (GM) and white matter (WM), total cortical GM and total lobar WM, thalamus and cerebellum, and decreased ventricular volume over 7.5-months of abstinence. Volume increases in regional GM were significantly greater over 1-week to 1-month than from 1-month to 7.5-months of abstinence, indicating a non-linear rate of change in regional GM over 7.5-months. Overall, regional lobar WM showed linear volume increases over 7.5-months. With increasing age, smoking ALC showed lower frontal and total cortical GM volume recovery than non-smoking ALC. Despite significant volume increases, ALC showed smaller GM volumes in all regions, except the frontal cortex, than controls after 7.5-months of abstinence. ALC and controls showed no regional WM volume differences at any assessment point. In non-smoking ALC only, increasing regional GM and WM volumes were related to improving processing speed. Findings may indicate a differential rate of recovery of cell types/cellular components contributing to GM and WM volume during early abstinence, and that GM volume deficits persist after 7.5-months of sustained sobriety in this ALC cohort.
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影响因子：
4.2
作者：
Durazzo, Timothy C.;Cardenas, Valerie A.;Meyerhoff, Dieter J.
通讯作者：
Meyerhoff, Dieter J.
DOI：
10.1097/01.alc.0000167958.68586.3d
发表时间：
2005-06-01
影响因子：
3.2
作者：
Mertens, JR;Weisner, C;Walsh, K
通讯作者：
Walsh, K
DOI：
10.1111/j.1530-0277.2006.00060.x
发表时间：
2006-03-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Durazzo, TC;Gazdzinski, S;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ
DOI：
10.1111/j.1530-0277.2011.01452.x
发表时间：
2011-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Durazzo TC;Tosun D;Buckley S;Gazdzinski S;Mon A;Fryer SL;Meyerhoff DJ
通讯作者：
Meyerhoff DJ
影响因子：
4.2
作者：
Durazzo TC;Meyerhoff DJ;Nixon SJ
通讯作者：
Nixon SJ