Age-related changes in grey and white matter structure throughout adulthood.
Age-related changes in grey and white matter structure throughout adulthood.
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DOI：
10.1016/j.neuroimage.2010.03.004
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发表时间：
2010-07-01
期刊：
影响因子：
5.7
通讯作者：
Johansen-Berg, Heidi
中科院分区：
文献类型：
--
作者：
Giorgio, Antonio;Santelli, Luca;Tomassini, Valentina;Bosnell, Rose;Smith, Steve;De Stefano, Nicola;Johansen-Berg, Heidi
正常的衰老与逐渐的脑萎缩有关。确定变化的空间和时间模式有助于揭示潜在的机制。神经影像学提供了各种脑结构的测量方法，可用于评估这种与年龄相关的变化，但迄今为止的研究通常只考虑单一的成像测量。虽然人们一致认为大脑结构会随着年龄的增长而退化，但关于确切的时间进程和变化的空间分布的证据是混合的。我们评估了一组66名年龄在23岁至81岁之间的成年人的灰质（GM）和白色物质（WM）结构。多模态成像测量包括基于体素的形态测量（VBM）风格的GM和WM体积分析和WM微观结构的扩散张量成像（DTI）指标。我们发现，从中年开始，GM体积普遍减少，但在额叶皮层中检测到GM的早期减少。广泛的年龄相关的恶化WM微观结构检测到从年轻的成年期开始。与传统T1加权成像的WM体积标记相比，使用基于DTI的微结构测量更早且更敏感地检测到WM下降。
Normal ageing is associated with gradual brain atrophy. Determining spatial and temporal patterns of change can help shed light on underlying mechanisms. Neuroimaging provides various measures of brain structure that can be used to assess such age-related change but studies to date have typically considered single imaging measures. Although there is consensus on the notion that brain structure deteriorates with age, evidence on the precise time course and spatial distribution of changes is mixed. We assessed grey matter (GM) and white matter (WM) structure in a group of 66 adults aged between 23 and 81. Multimodal imaging measures included voxel-based morphometry (VBM)-style analysis of GM and WM volume and diffusion tensor imaging (DTI) metrics of WM microstructure. We found widespread reductions in GM volume from middle age onwards but earlier reductions in GM were detected in frontal cortex. Widespread age-related deterioration in WM microstructure was detected from young adulthood onwards. WM decline was detected earlier and more sensitively using DTI-based measures of microstructure than using markers of WM volume derived from conventional T1-weighted imaging.
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