Agitation and Irritability in Alzheimer's Disease: Evidenced-Based Treatments and the Black-Box Warning.
Agitation and Irritability in Alzheimer's Disease: Evidenced-Based Treatments and the Black-Box Warning.
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阿尔茨海默氏病的躁动和烦恼：基于证据的治疗方法和黑盒警告。
DOI：
10.1007/s11920-015-0640-7
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发表时间：
2016-01
影响因子：
6.7
通讯作者：
Streim JE
中科院分区：
文献类型：
--
作者：
Koenig AM;Arnold SE;Streim JE
超过 500 万美国人患有阿尔茨海默病 (AD)，预计到 2050 年这一数字将增加两倍。虽然认知（尤其是记忆）损伤通常是该临床综合征的典型特征，但行为症状极为常见，影响高达 90% 的患者。 AD 的行为症状可能难以控制，可能需要结合非药物和药物方法。 FDA 对最常用于针对这些症状的药物类别发出“黑箱警告”，使后者变得复杂，目前已采取措施限制其使用。在这篇综述中，我们描述了 AD 的常见行为症状，特别关注“激越”和“易怒”等具有挑战性的症状，并讨论了基于证据的治疗方法。最终，建议采用针对患者及其环境的多维方法，并且应在可行的情况下使用基于证据的实践。
More than five million Americans suffer from Alzheimer’s disease (AD), and this number is expected to triple by 2050. While impairments in cognition, particularly memory, are typically the defining features of the clinical syndrome, behavioral symptoms are extremely common, affecting up to 90% of patients. Behavioral symptoms in AD can be difficult to manage and may require a combination of non-pharmacological and pharmacological approaches. The latter is complicated by FDA “black-box warnings” for the medication classes most often used to target these symptoms, and currently there are initiatives in place to limit their use. In this review, we describe common behavioral symptoms of AD—with a particular focus on the challenging symptoms of “agitation” and “irritability”—and discuss evidence-based approaches to their management. Ultimately, multidimensional approaches tailored to the patient and their environment are recommended, and evidence-based practices should be used when available.
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影响因子：
4
作者：
Ma, Hui;Huang, Yinglin;Zhu, Gang
通讯作者：
Zhu, Gang
影响因子：
2.4
作者：
Burns, Alistair;Perry, Elaine;Ballard, Clive
通讯作者：
Ballard, Clive
影响因子：
38.1
作者：
Fong, Tamara G.;Tulebaev, Samir R.;Inouye, Sharon K.
通讯作者：
Inouye, Sharon K.
DOI：
10.1016/j.jamda.2014.12.018
发表时间：
2015-05-01
影响因子：
7.6
作者：
Brodaty, Henry;Connors, Michael H.;Ames, David
通讯作者：
Ames, David
影响因子：
6.7
作者：
Borisovskaya, Anna;Pascualy, Marcella;Borson, Soo
通讯作者：
Borson, Soo