B cell activating factor in obesity is regulated by oxidative stress in adipocytes.
B cell activating factor in obesity is regulated by oxidative stress in adipocytes.
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DOI：
10.3164/jcbn.12-115
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发表时间：
2013-03
影响因子：
2.4
通讯作者：
Onji M
中科院分区：
文献类型：
--
作者：
Tada F;Abe M;Kawasaki K;Miyake T;Shiyi C;Hiasa Y;Matsuura B;Onji M
脂肪组织作为关键的内分泌器官，通过释放多种生物活性物质，在全身代谢的整合中起着关键作用。我们之前已经证明B细胞激活因子主要在内脏脂肪组织中产生，并影响肥胖者的胰岛素敏感性。在这项研究中，我们确定了导致脂肪细胞产生B细胞激活因子的信号。3T3-L1和C3H/10T1/2-Clone 8细胞在过氧化氢作用下B细胞活化因子表达增加，抗氧化剂N-乙酰半胱氨酸可抑制这种变化。高脂饲料喂养的小鼠血清和内脏脂肪组织中的B细胞激活因子水平均升高，这与氧化应激有关。此外，N-乙酰半胱氨酸还能降低高脂饲料喂养小鼠的血清BAFF水平。我们还发现，氧化应激诱导的脂肪细胞中B细胞激活因子的表达受NF-κB激活的调节。这些数据表明，控制内脏脂肪组织中的氧化还原状态是通过调节脂肪因子的产生来治疗代谢综合征的潜在有用的靶点。
Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, and plays a key role in the integration of systemic metabolism. We have previously shown that B cell activating factor is produced mainly in visceral adipose tissue and affects insulin sensitivity in obese individuals. In this study, we identified the signals that lead to production of B cell activating factor in adipocytes. 3T3-L1 and C3H/10T 1/2-clone 8 cells showed increased B cell activating factor expression upon exposure to hydrogen peroxide, and these changes were inhibited by treatment with the antioxidant N-acetyl-cysteine. B cell activating factor levels in both serum and visceral adipose tissue were increased in high fat diet-fed mice, and these increases were correlated with oxidative stress. In addition, serum BAFF levels in high fat diet-fed mice were reduced by N-acetyl-cysteine treatment. We also found that oxidative stress-induced B cell activating factor expression in adipocytes was regulated by NF-κB activation. These data indicate that control of the redox state in visceral adipose tissue is a potentially useful target for treating metabolic syndromes through regulation of adipokine production.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
炎症和代谢疾病中的脂肪因子。
DOI：
10.1038/nri2921
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
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作者：
Pelekanou V;Kampa M;Kafousi M;Darivianaki K;Sanidas E;Tsiftsis DD;Stathopoulos EN;Tsapis A;Castanas E
通讯作者：
Castanas E
影响因子：
7.4
作者：
Moon, Eun-Yi;Lee, Jun-Hee;Yoon, Won-Kee
通讯作者：
Yoon, Won-Kee
影响因子：
120.7
作者：
Mokdad, AH;Ford, ES;Marks, JS
通讯作者：
Marks, JS