Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas.
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas.
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TNF-Superfamily成员BAFF和April在乳腺癌中的表达：52个浸润性导管性乳腺癌中的免疫组织化学研究。
DOI：
10.1186/1471-2407-8-76
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发表时间：
2008-03-20
期刊：
影响因子：
3.8
通讯作者：
Castanas E
中科院分区：
文献类型：
--
作者：
Pelekanou V;Kampa M;Kafousi M;Darivianaki K;Sanidas E;Tsiftsis DD;Stathopoulos EN;Tsapis A;Castanas E
最近的研究表明，慢性炎症、调节组织微环境和肿瘤生物学之间存在关联。肿瘤环境由肿瘤、间质和内皮细胞以及浸润性巨噬细胞、T淋巴细胞和树突状细胞组成，产生一系列细胞因子、趋化因子和生长因子，参与复杂的细胞相互作用和对肿瘤及其周围细胞的分化、激活、功能和生存的调节，负责肿瘤的进展和抗肿瘤免疫反应和排斥反应的扩散或诱导。肿瘤坏死因子家族成员(19个配体和29个受体)是一个多向作用的家族，与从增殖和分化到细胞凋亡和肿瘤减少等一系列细胞事件有关。在这些成员中，BAFF和APRIL(分别为CD257和CD256)由于在许多淋巴细胞、上皮和间质结构中的细胞保护、分化和生长方面的作用而受到越来越多的关注。我们用免疫组织化学方法检测了52例人乳腺癌活检组织中BAFF和APRIL的表达，并将我们的发现与临床病理数据和疾病的演变相关联。BAFF广泛表达于乳腺癌细胞、DCIS、正常腺管及瘤周脂肪细胞。相反，与恶性乳腺结构相比，非恶性乳腺组织中APRIL免疫反应阳性表达更高。在N+肿瘤中，APRIL而不是BAFF免疫反应性较高，且与肿瘤的分级呈负相关。这两个参数均与DFS或患者的OS无关。我们的数据首次显示乳腺癌细胞自分泌BAFF和APRIL，为它们在肿瘤和正常乳腺细胞生物学中的作用提供了新的视角，并为可能的乳腺癌选择性干预提供了新的视角。
Recent studies suggest an association between chronic inflammation, modulating the tissue microenvironment, and tumor biology. Tumor environment consists of tumor, stromal and endothelial cells and infiltrating macrophages, T lymphocytes, and dendritic cells, producing an array of cytokines, chemokines and growth factors, accounting for a complex cell interaction and regulation of differentiation, activation, function and survival of tumor and surrounding cells, responsible for tumor progression and spreading or induction of antitumor immune responses and rejection. Tumor Necrosis Factor (TNF) family members (19 ligands and 29 receptors) represent a pleiotropic family of agents, related to a plethora of cellular events from proliferation and differentiation to apoptosis and tumor reduction. Among these members, BAFF and APRIL (CD257 and CD256 respectively) gained an increased interest, in view of their role in cell protection, differentiation and growth, in a number of lymphocyte, epithelial and mesenchymal structures. We have assayed by immunohistochemistry 52 human breast cancer biopsies for the expression of BAFF and APRIL and correlated our findings with clinicopathological data and the evolution of the disease. BAFF was ubiquitely expressed in breast carcinoma cells, DCIS, normal-appearing glands and ducts and peritumoral adipocytes. In contrast, APRIL immunoreactive expression was higher in non-malignant as compared to malignant breast structures. APRIL but not BAFF immunoreactivity was higher in N+ tumors, and was inversely related with the grade of the tumors. Neither parameter was related to DFS or the OS of patients. Our data show, for the first time, an autocrine secretion of BAFF and APRIL from breast cancer cells, offering new perspectives for their role in neoplastic and normal breast cell biology and offering new perspectives for possible selective intervention in breast cancer.
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影响因子：
2.9
作者：
Guan, Zheng-Bing;Dan, Wen-Bing;Zhang, Shuang-Quan
通讯作者：
Zhang, Shuang-Quan
影响因子：
4.4
作者：
GRAS, MP;LAABI, Y;TSAPIS, A
通讯作者：
TSAPIS, A
影响因子：
12.4
作者：
Hendriks, J;Planelles, L;Medema, JP
通讯作者：
Medema, JP
April是肿瘤坏死因子家族的新配体，刺激肿瘤细胞生长。
影响因子：
15.3
作者：
Hahne, M;Kataoka, T;Schroter, M;Hofmann, K;Irmler, M;Bodmer, J L;Schneider, P;Bornand, T;Holler, N;French, L E;Sordat, B;Rimoldi, D;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
12.4
作者：
Cawthorn, W. P.;Heyd, F.;Hegyi, K.;Sethi, J. K.
通讯作者：
Sethi, J. K.