Connectome the Dots for Presurgical Predictions.
Connectome the Dots for Presurgical Predictions.
复制标题
connectome用于术前预测的点。
DOI：
10.1177/15357597221125221
复制
发表时间：
2022-11
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
术前颞叶癫痫连接组指纹用于癫痫发作结局预测Morgan VL，Sainburg LE，约翰逊GW，Janson A，Levine KK，Rogers BP，Chang C，Englot DJ. Brain Comm. 2022;4（3）：fcac128. doi：10.1093/braincomms/fcac 128颞叶癫痫是一种独特的情况，在颞叶内侧手术后，癫痫病灶的可靠临床定位并不总是导致无癫痫或有利的结局。在这项工作中，磁共振成像衍生的功能和结构全脑连接被用来计算网络指纹，该指纹捕获了这些患者中9名患者的连接特征，这些患者具有无脑损伤的结果。然后计算38名遗漏患者的连通性概况，假设与指纹的相似性表明无创伤手术结果。将患者轮廓到指纹的距离与1年癫痫发作结局和标准临床参数进行比较。与Engel Ia、Ib-d和II型结局患者相比，Engel III-IV型1年结局患者与指纹的距离更高（Kruskal-Wallis，P < 0.01; Wilcoxon秩和pcorr <0.05 Bonferroni校正）。受试者操作者特征分析显示，根据与遗漏患者指纹的距离，识别Engel III-IV结局患者的敏感性为100%，特异性为90%。此外，到指纹的距离与任何个体临床参数无关，包括扫描时的年龄、疾病持续时间、总发作频率、内侧颞叶硬化、偏侧发作、发作间期头皮脑电图、侵入性立体脑电描记术或正电子发射断层扫描。两种已发表的算法利用多种临床指标预测癫痫发作结局，与指纹的距离无关，也不能预测该队列中的癫痫发作结局。功能和结构连接体指纹提供了单独或组合的标准临床评估无法捕获的定量、临床可解释和重要信息。这种自动化和简单的方法可能会提高患者的癫痫发作的结果与临床确定的病灶在内侧颞叶的患者的具体预测。
Presurgical Temporal Lobe Epilepsy Connectome Fingerprint for Seizure Outcome Prediction Morgan VL, Sainburg LE, Johnson GW, Janson A, Levine KK, Rogers BP, Chang C, Englot DJ. Brain Comm. 2022;4(3):fcac128. doi:10.1093/braincomms/fcac128 Temporal lobe epilepsy presents a unique situation where confident clinical localization of the seizure focus does not always result in a seizure-free or favourable outcome after mesial temporal surgery. In this work, magnetic resonance imaging derived functional and structural whole-brain connectivity was used to compute a network fingerprint that captures the connectivity profile characteristics that are common across a group of nine of these patients with seizure-free outcome. The connectivity profile was then computed for 38 left-out patients with the hypothesis that similarity to the fingerprint indicates seizure-free surgical outcome. Patient profile distance to the fingerprint was compared with 1-year seizure outcome and standard clinical parameters. Distance to the fingerprint was higher for patients with Engel III-IV 1-year outcome compared with those with Engel Ia, Ib-d, and II outcome (Kruskal-Wallis, P < 0.01; Wilcoxon rank-sum pcorr <0.05 Bonferroni-corrected). Receiver operator characteristic analysis revealed 100% sensitivity and 90% specificity in identifying patients with Engel III-IV outcome based on distance to the fingerprint in the left-out patients. Furthermore, distance to the fingerprint was not related to any individual clinical parameter including age at scan, duration of disease, total seizure frequency, presence of mesial temporal sclerosis, lateralizing ictal, interictal scalp electroencephalography, invasive stereo-encephalography, or positron emission tomography. And two published algorithms utilizing multiple clinical measures for predicting seizure outcome were not related to distance to the fingerprint, nor predictive of seizure outcome in this cohort. The functional and structural connectome fingerprint provides quantitative, clinically interpretable and significant information not captured by standard clinical assessments alone or in combinations. This automated and simple method may improve patient-specific prediction of seizure outcome in patients with a clinically identified focus in the mesial temporal lobe.
登录
查看更多内容
DOI：
10.1016/j.yebeh.2015.04.033
发表时间：
2015-06
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Chang EF;Englot DJ;Vadera S
通讯作者：
Vadera S
影响因子：
4.1
作者：
Borger, Valeri;Hamed, Motaz;Vatter, Hartmut
通讯作者：
Vatter, Hartmut
影响因子：
29
作者：
Chen, Zhibin;Brodie, Martin J.;Kwan, Patrick
通讯作者：
Kwan, Patrick
影响因子：
5.6
作者：
Haneef Z;Lenartowicz A;Yeh HJ;Levin HS;Engel J Jr;Stern JM
通讯作者：
Stern JM
影响因子：
5.6
作者：
Scott, Rod C.;de la Prida, Liset Menendez;de Curtis, Marco
通讯作者：
de Curtis, Marco