Ocular axial length and its associations in Chinese: the Beijing Eye Study.
Ocular axial length and its associations in Chinese: the Beijing Eye Study.
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中文眼轴长度及其关联：北京眼科研究
DOI：
10.1371/journal.pone.0043172
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Beijing Eye Study Group
中科院分区：
文献类型：
--
作者：
Yin G;Wang YX;Zheng ZY;Yang H;Xu L;Jonas JB;Beijing Eye Study Group
目的探讨中国人眼轴长度的规范性数据及其相关性。方法基于人群的2011年北京眼科研究是在大北京地区进行的一项横断面研究。该研究包括3468例个体（1963例（56.6%）为女性），平均年龄为64.6±9.8岁（范围：50-93岁）。进行了详细的眼科和医学检查。用光学低相干反射法测量轴向长度。结果3159名（91.1%）研究参与者进行了轴向长度测量。平均轴长23.25±1.14 mm（范围：18.96 ~ 30.88 mm）。在多因素分析中，眼轴长度与年龄较高（P<0.001）、身高较高（P = 0.003）、文化程度较高（P<0.001）、居住城市地区（P<0.001）等系统参数显著相关，与中央角膜较厚（P = 0.001）、角膜曲率半径较高（P<0.001）、前房较深（P<0.001）、晶状体较厚（P<0.001）、近视眼屈光不正较多（P<0.001）、瞳孔直径较大（P = 0.018）、角膜屈光不正发生率较高（P<0.001）、角膜屈光不正发生率较高（P = 0.018）等眼部参数显著相关。和较高的最佳矫正视力（P<0.001）。此外，它与晶状体穹窿呈负相关（P<0.001）。高度近视眼的视轴长度与受教育程度低（P = 0.008）、近视屈光不正（P<0.001）和最佳矫正视力低（P = 0.034）显著相关。结论大北京地区老年人群平均眼轴长度（23.25±1.14 mm）与其他城市人群相似，高于中部印度农村人群。轴向长度和老年之间的关联可能潜在地与生存神器有关。轴长和身体高度之间的关系与拟人化测量和眼球大小之间的一般关系一致。与教育水平和居住城市地区的关系与先前的研究相证实。高度近视眼的视轴长度与受教育程度和最佳矫正视力呈负相关。
Purpose To investigate the normative data of ocular axial length and its associations in Chinese. Method The population-based Beijing Eye Study 2011 is a cross-sectional study performed in Greater Beijing. The study included 3468 individuals (1963 (56.6%) women) with a mean age of 64.6±9.8 years (range: 50–93 years). A detailed ophthalmic and medical examination was performed. Axial length was measured by optical low-coherence reflectometry. Results Axial length measurements were available for 3159 (91.1%) study participants. Mean axial length was 23.25±1.14 mm (range: 18.96–30.88 mm). In multivariate analysis, axial length was significantly associated with the systemic parameters of higher age (P<0.001), higher body height (P = 0.003), higher level of education (P<0.001) and urban region of habitation (P<0.001), and with the ocular parameters of thicker central cornea (P = 0.001), higher corneal curvature radius (P<0.001), deeper anterior chamber (P<0.001), thicker lens (P<0.001), more myopic refractive error (P<0.001), larger pupil diameter (P = 0.018), and higher best corrected visual acuity (P<0.001). It was additionally and negatively associated with the lens vault (P<0.001). In highly myopic eyes, axial length was significantly associated with lower level of education (P = 0.008), more myopic refractive error (P<0.001), and lower best corrected visual acuity (P = 0.034). Conclusions Mean ocular axial length in the older adult population of Greater Beijing (23.25±1.14 mm) was similar to the value measured in other urban populations and was higher than in a rural Central Indian population. The association between axial length and older age may potentially be associated with a survival artifact. The association between axial length and body height agrees with the general association between anthropomorphic measures and eye globe size. The association with the level of education and urban region of habitation confirms with previous studies. In contrast in highly myopic eyes, axial length was negatively associated with educational level and best corrected visual acuity.
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影响因子：
13.7
作者：
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通讯作者：
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