Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry.
Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry.
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DOI：
10.1021/mp3005325
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发表时间：
2013-03-04
影响因子：
4.9
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Lo ST;Kumar A;Hsieh JT;Sun X
树枝状聚合物是一类结构明确的大分子，其特征在于具有中心核、由重复支化单元形成的低密度内部和由表面官能团封端的高密度外部。与聚合物相比，树枝状聚合物具有纳米尺寸和对称形状，可以大规模重复合成，具有单分散性。这些独特的功能使得树枝状聚合物作为纳米支架系统在药物递送和其他生物医学应用中越来越受到关注。旨在解决潜在的使用树枝状聚合物的治疗诊断剂的发展，它结合了治疗和诊断在一个单一的实体个性化的医疗，这篇评论的重点是报告的方法，使用树枝状聚合物nanoscaffolds有针对性的成像和治疗前列腺癌。特别感兴趣的是，相关的化学策略进行了讨论，由于其在诊断和治疗的树枝状聚合物为基础的nanoconjugates和潜在的治疗诊断剂，有针对性的或非有针对性的设计和合成的重要作用。鉴于nanoscaffolded治疗诊断学的发展现状，主要的挑战和潜在的障碍进行了讨论，沿着的例子代表当前的进展。
Dendrimers are a class of structurally defined macromolecules featured with a central core, a low-density interior formed by repetitive branching units, and a high-density exterior terminated with surface functional groups. In contrast to their polymeric counterparts, dendrimers are nano-sized and symmetrically shaped, which can be reproducibly synthesized in a large scale with monodispersity. These unique features have made dendrimers of increasing interest for drug delivery and other biomedical applications as a nanoscaffold system. Intended to address the potential use of dendrimers for the development of theranostic agents, which combines therapeutics and diagnostics in a single entity for personalized medicine, this review focuses on the reported methodologies of using dendrimer nanoscaffolds for targeted imaging and therapy of prostate cancer. Of particular interest, relevant chemistry strategies are discussed due to their important roles in the design and synthesis of diagnostic and therapeutic dendrimer-based nanoconjugates and potential theranostic agents, targeted or non-targeted. Given the developing status of nanoscaffolded theranostics, major challenges and potential hurdles are discussed along with the examples representing current advances.
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影响因子：
5.1
作者：
Almushayt, A;Narayanan, K;George, A
通讯作者：
George, A
影响因子：
64.5
作者：
BROOKS, PC;MONTGOMERY, AMP;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
56.9
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
通讯作者：
CHERESH, DA
DOI：
10.1034/j.1399-3011.1999.00055.x
发表时间：
1999-05-01
期刊：
JOURNAL OF PEPTIDE RESEARCH
影响因子：
--
作者：
Bogdanowich-Knipp, SJ;Jois, DSS;Siahaan, TJ
通讯作者：
Siahaan, TJ
DOI：
10.1034/j.1399-3011.1999.00052.x
发表时间：
1999-05-01
期刊：
JOURNAL OF PEPTIDE RESEARCH
影响因子：
--
作者：
Bogdanowich-Knipp, SJ;Chakrabarti, S;Siahaan, TJ
通讯作者：
Siahaan, TJ