A roadmap for the functional annotation of protein families: a community perspective.
A roadmap for the functional annotation of protein families: a community perspective.
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DOI：
10.1093/database/baac062
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发表时间：
2022-08-12
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影响因子：
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在过去的25年里，生物学已经进入了基因组时代，并正在成为一门“大数据”科学。基因组分析的大多数解释依赖于迄今为止测序的50多万个基因组编码的蛋白质的准确功能注释。根据不同的估计，只有一半的预测测序蛋白质携带准确的功能注释，并且这个百分比在不同的生物谱系之间变化很大。如此巨大的知识差距阻碍了生物事业的各个方面，从而阻碍了基因组生物学充分发挥其潜力。由美国国家科学基金会资助的解决这一问题的头脑风暴会议于2022年2月3日至4日举行。将数据科学家、生物学家、计算生物学家和实验学家聚集在同一地点，可以全面评估蛋白质家族功能注释的现状。此外，还查明并讨论了妨碍实地工作的主要问题，最终得以就如何向前推进提出解决办法。
Over the last 25 years, biology has entered the genomic era and is becoming a science of ‘big data’. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by more than 500 000 genomes sequenced to date. By different estimates, only half the predicted sequenced proteins carry an accurate functional annotation, and this percentage varies drastically between different organismal lineages. Such a large gap in knowledge hampers all aspects of biological enterprise and, thereby, is standing in the way of genomic biology reaching its full potential. A brainstorming meeting to address this issue funded by the National Science Foundation was held during 3–4 February 2022. Bringing together data scientists, biocurators, computational biologists and experimentalists within the same venue allowed for a comprehensive assessment of the current state of functional annotations of protein families. Further, major issues that were obstructing the field were identified and discussed, which ultimately allowed for the proposal of solutions on how to move forward.
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影响因子：
14.9
作者：
Gene Ontology Consortium
通讯作者：
Gene Ontology Consortium
影响因子：
--
作者：
Altaf-Ul-Amin M;Afendi FM;Kiboi SK;Kanaya S
通讯作者：
Kanaya S
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
7.7
作者：
Breuer, Marian;Earnest, Tyler M.;Luthey-Schulten, Zaida
通讯作者：
Luthey-Schulten, Zaida
影响因子：
5.5
作者：
Baltoumas FA;Zafeiropoulou S;Karatzas E;Koutrouli M;Thanati F;Voutsadaki K;Gkonta M;Hotova J;Kasionis I;Hatzis P;Pavlopoulos GA
通讯作者：
Pavlopoulos GA