Long-term administration of yoghurt improves spatial memory in mice
Long-term administration of yoghurt improves spatial memory in mice
复制标题
长期服用酸奶可改善小鼠的空间记忆
DOI:
--
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发表时间:
2019
期刊:
影响因子:
--
通讯作者:
M. Furuse
中科院分区:
文献类型:
--
作者:
Takahiro Kawase;M. Furuse
Gut microbiota modulate host behavior by altering their brain function through vagal nerve stimulation, the immune system, or the release of hormones. We recently reported that the gut microbiota modifies free amino acid concentrations in the brain. Although many studies of functional lactobacillus have been reported, the role of lactobacillus in learning ability has not been clarified. Cognitive dysfunction syndrome with aging causes abnormal behavior and memory disorders in many animals, including humans, dogs or cats. We investigated the effect of long-term administration of yoghurt(fermented by Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131)on the spatial memory and amino acid and monoamine concentrations in the cerebral cortex of mice. Long-term administration of yoghurt improved the test scores for spatial reference memory on the eight-arm radial maze and increased 5-hydroxytryptamine, and the cerebral cortex concentrations of free L-alanine, Dand L-serine, L-valine, and L-isoleucine. These results suggest that the long-term intake of yoghurt by mice might improve the spatial reference memory through modification of the metabolism of several amino acids and 5-hydroxytryptamine in the cerebral cortex. J. Pet Anim. Nutr., Vol. 22(No. 1): 1-13. 2019
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影响因子:
37.8
作者:
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者:
Kannel, WB
影响因子:
29.4
作者:
Tillisch K;Labus J;Kilpatrick L;Jiang Z;Stains J;Ebrat B;Guyonnet D;Legrain-Raspaud S;Trotin B;Naliboff B;Mayer EA
通讯作者:
Mayer EA
影响因子:
2.1
作者:
Wu,Shengzhou;Basile,AnthonyS;Barger,StevenW
通讯作者:
Barger,StevenW
影响因子:
8.8
作者:
Bijata, Monika;Labus, Josephine;Ponimaskin, Evgeni
通讯作者:
Ponimaskin, Evgeni
DOI:
10.1073/pnas.93.20.11219
发表时间:
1996-10-01
影响因子:
11.1
作者:
Bakin, JS;Weinberger, NM
通讯作者:
Weinberger, NM