Long-term administration of yoghurt improves spatial memory in mice

Long-term administration of yoghurt improves spatial memory in mice
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长期服用酸奶可改善小鼠的空间记忆

DOI:
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发表时间:
2019
期刊:
影响因子:
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通讯作者:
M. Furuse
M. Furuse
中科院分区:
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文献类型:
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作者:
Takahiro Kawase;M. Furuse

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肠道微生物群通过迷走神经刺激、免疫系统或激素释放来改变宿主的大脑功能,从而调节宿主的行为。我们最近报道,肠道微生物群改变了大脑中的游离氨基酸浓度。虽然许多关于功能性学习的研究已经被报道,但学习能力中的功能性学习的作用还没有被阐明。认知功能障碍综合征与衰老导致异常的行为和记忆障碍,在许多动物,包括人类,狗或猫。我们研究了长期服用酸奶(由德氏乳杆菌亚种发酵)的效果。保加利亚2038和嗜热链球菌1131)对小鼠的空间记忆以及大脑皮层中的氨基酸和单胺浓度的影响。长期给予酸奶改善了八臂径向迷宫空间参考记忆的测试分数,并增加了5-羟色胺,以及大脑皮层游离L-丙氨酸,D和L-丝氨酸,L-缬氨酸和L-异亮氨酸的浓度。提示长期饮用酸奶可能通过改变小鼠大脑皮层氨基酸和5-羟色胺的代谢而改善空间参考记忆。J. Pet Anim.天然气:第22卷(第1期):1-13。2019
Gut microbiota modulate host behavior by altering their brain function through vagal nerve stimulation, the immune system, or the release of hormones. We recently reported that the gut microbiota modifies free amino acid concentrations in the brain. Although many studies of functional lactobacillus have been reported, the role of lactobacillus in learning ability has not been clarified. Cognitive dysfunction syndrome with aging causes abnormal behavior and memory disorders in many animals, including humans, dogs or cats. We investigated the effect of long-term administration of yoghurt(fermented by Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131)on the spatial memory and amino acid and monoamine concentrations in the cerebral cortex of mice. Long-term administration of yoghurt improved the test scores for spatial reference memory on the eight-arm radial maze and increased 5-hydroxytryptamine, and the cerebral cortex concentrations of free L-alanine, Dand L-serine, L-valine, and L-isoleucine. These results suggest that the long-term intake of yoghurt by mice might improve the spatial reference memory through modification of the metabolism of several amino acids and 5-hydroxytryptamine in the cerebral cortex. J. Pet Anim. Nutr., Vol. 22(No. 1): 1-13. 2019
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