Ebolaviruses: New roles for old proteins.
Ebolaviruses: New roles for old proteins.
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DOI：
10.1371/journal.pntd.0006349
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发表时间：
2018-05
影响因子：
3.8
通讯作者：
Rossman JS
中科院分区：
文献类型：
--
作者：
Cantoni D;Rossman JS
2014年，世界见证了有史以来最大规模的埃博拉疫情。随后的人道主义努力促进了广泛的研究，大大提高了我们对埃博拉病毒复制和致病性的认识。自1976年发现埃博拉病毒以来，对每种埃博拉病毒蛋白的主要功能进行了广泛研究；然而，最近埃博拉病毒研究的扩大导致了新的蛋白质功能的发现。这些新发现的作用揭示了病毒复制和致病性的新机制，同时增强了我们对每种埃博拉病毒蛋白（VP）广泛功能的理解。许多这些新功能似乎与病毒复制过程中蛋白质的主要功能无关。这些新功能包括由vp40分泌的外泌体引起的旁观者t淋巴细胞死亡，以及VP24在病毒颗粒形成中的新作用。这篇综述强调了埃博拉病毒蛋白新发现的作用，以便对埃博拉病毒的复制和致病性提供更全面的看法。2014年至2016年期间，西非经历了有史以来最大规模的埃博拉疫情。国际遏制努力促进了广泛的研究，增强了我们对埃博拉病毒复制和致病性的认识。自1976年发现埃博拉病毒以来，人们对每种埃博拉病毒蛋白的主要功能已经了解了很多；然而，最近对埃博拉病毒的研究发现了许多新的蛋白质功能。这些新发现的角色揭示了病毒复制和发病机制的新机制，并增加了我们对病毒每个组成部分如何工作的理解。这篇综述强调了埃博拉病毒蛋白新发现的作用，以便对埃博拉病毒的复制和致病性提供更全面的看法。
In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein’s primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity. Between 2014 and 2016, West Africa experienced the largest Ebolavirus outbreak in recorded history. The international containment effort spurred extensive research that is enhancing our understanding of ebolavirus replication and pathogenicity. Much has been learned about the main function of each ebolavirus protein since the discovery of the virus in 1976; however, recent ebolavirus research has led to the discovery of many new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenesis and increasing our understanding of how each component of the virus works. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity.
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影响因子：
3.7
作者：
Beniac DR;Melito PL;Devarennes SL;Hiebert SL;Rabb MJ;Lamboo LL;Jones SM;Booth TF
通讯作者：
Booth TF
DOI：
10.1056/nejmoa1511410
发表时间：
2017-10-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Deen GF;Broutet N;Xu W;Knust B;Sesay FR;McDonald SLR;Ervin E;Marrinan JE;Gaillard P;Habib N;Liu H;Liu W;Thorson AE;Yamba F;Massaquoi TA;James F;Ariyarajah A;Ross C;Bernstein K;Coursier A;Klena J;Carino M;Wurie AH;Zhang Y;Dumbuya MS;Abad N;Idriss B;Wi T;Bennett SD;Davies T;Ebrahim FK;Meites E;Naidoo D;Smith SJ;Ongpin P;Malik T;Banerjee A;Erickson BR;Liu Y;Liu Y;Xu K;Brault A;Durski KN;Winter J;Sealy T;Nichol ST;Lamunu M;Bangura J;Landoulsi S;Jambai A;Morgan O;Wu G;Liang M;Su Q;Lan Y;Hao Y;Formenty P;Ströher U;Sahr F
通讯作者：
Sahr F
影响因子：
4.8
作者：
Cantoni D;Hamlet A;Michaelis M;Wass MN;Rossman JS
通讯作者：
Rossman JS
影响因子：
6.7
作者：
Chang TH;Kubota T;Matsuoka M;Jones S;Bradfute SB;Bray M;Ozato K
通讯作者：
Ozato K
影响因子：
5
作者：
Groseth, A.;Charton, J. E.;Sauerborn, M.;Feldmann, F.;Jones, S. M.;Hoenen, T.;Feldmann, H.
通讯作者：
Feldmann, H.