chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.
chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila.
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DOI：
10.1016/j.devcel.2010.02.006
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发表时间：
2010-04-20
影响因子：
11.8
通讯作者：
Bach, Erika A.
中科院分区：
文献类型：
--
作者：
Flaherty, Maria Sol;Salis, Pauline;Evans, Cory J.;Ekas, Laura A.;Marouf, Amine;Zavadil, Jiri;Banerjee, Uptal;Bach, Erika A.
果蝇STAT转录因子Stat92E调节多种功能，包括器官发育和干细胞自我更新。然而，介导这些过程的Stat92E功能效应器在很大程度上是未知的。在这里，我们发现chinmo是Stat92E的细胞自主下游介质，与该蛋白共享许多功能。由于眼祖细胞的缺陷，任何一种基因的缺失都会导致眼睛和头囊畸形。Stat92E的过度激活或Chinmo的错误表达导致血细胞肿瘤。这两种蛋白都在睾丸的种系细胞（GSCs）和囊肿干细胞（CySCs）中表达。两种细胞的自我更新都需要Stat92E，而chinmo仅在CySCs中需要，这表明Stat92E通过独立的效应物调节不同干细胞的自我更新。与过度激活的Stat92E一样，CySCs中的Chinmo错表达足以维持GSCs的非自主性。因此，Chinmo是多种发育和病理背景下JAK/STAT信号传导的关键效应因子。
The Drosophila STAT transcription factor Stat92E regulates diverse functions, including organ development and stem cell self-renewal. However, the Stat92E functional effectors that mediate these processes are largely unknown. Here we show that chinmo is a cell-autonomous, downstream mediator of Stat92E that shares numerous functions with this protein. Loss of either gene results in malformed eyes and head capsules due to defects in eye progenitor cells. Hyperactivation of Stat92E or misexpression of Chinmo results in blood cell tumors. Both proteins are expressed in germline (GSCs) and cyst stem cells (CySCs) in the testis. While Stat92E is required for the self-renewal of both populations, chinmo is only required in CySCs, indicating that Stat92E regulates self-renewal in different stem cells through independent effectors. Like hyperactivated Stat92E, Chinmo misexpression in CySCs is sufficient to maintain GSCs non-autonomously. Chinmo is therefore a key effector of JAK/STAT signaling in a variety of developmental and pathological contexts.
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影响因子：
30.8
作者：
Dupuis, S;Jouanguy, E;Casanova, JL
通讯作者：
Casanova, JL
影响因子：
6.7
作者：
Gissel, C;Voolstra, C;Sachinidis, A
通讯作者：
Sachinidis, A
影响因子：
1.2
作者：
Bach, Erika A.;Ekas, Laura A.;Baeg, Gyeong-Hun
通讯作者：
Baeg, Gyeong-Hun
DOI：
10.1007/bf00279527
发表时间：
1993-04-01
期刊：
MOLECULAR & GENERAL GENETICS
影响因子：
--
作者：
HANRATTY, WP;DEAROLF, CR
通讯作者：
DEAROLF, CR
影响因子：
11.8
作者：
Decotto, E;Spradling, AC
通讯作者：
Spradling, AC