Alterations of brain metrics in fetuses of women with polycystic ovary syndrome : a retrospective study based on fetal magnetic resonance imaging.
Alterations of brain metrics in fetuses of women with polycystic ovary syndrome : a retrospective study based on fetal magnetic resonance imaging.
复制标题
多囊卵巢综合征妇女胎儿大脑指标的改变：基于胎儿磁共振成像的回顾性研究
DOI：
10.1186/s12884-021-04015-w
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发表时间：
2021-08-14
影响因子：
3.1
通讯作者：
Qu F
中科院分区：
文献类型：
--
作者：
Bao Z;Zhang Q;Pan M;Xi X;Wang Y;Zhang F;Wang F;Zou Y;Qu F
母体多囊卵巢综合征（PCOS）对后代的神经发育有潜在的不利影响。本研究旨在基于胎儿磁共振成像（MRI）评估多囊卵巢综合征（PCOS）女性胎儿的大脑指标。方法回顾性研究60例PCOS孕妇（PCOS组）和120例非PCOS孕妇（对照组）。在超声检查和许多临床适应症之后进行了胎儿MRI，包括已知或怀疑的胎儿病理，以前妊娠或家庭成员的胎儿异常史。分析胎儿脑生物特征及表观扩散系数（ADC）值。结果经潜在混杂因素校正后，PCOS组胎儿与对照组相比表现出以下特点：(1)脑枕额径（FOD）、蚓高（VH）、脑桥前后径（APDP）均小于对照组（P = 0.042、P = 0.002、P = 0.016）；(2)左右双顶叶指数增高（32周前比较明显，P = 0.048, P = 0.025）；(3)左侧脑室（LV）缩小（32周后比较明显，P = 0.005）；(4)蚓部前后径（APDV）和海马内折角（HIA）增大（32周后比较明显，P = 0.003和P = 0.001）；(5)大鼠额叶白质（FWM）和基底节区（BG） ADC值增高（32周前后均有统计学差异，p < 0.05）。结论PCOS子代在子宫内存在不同的脑指标模式。
BackgroundMaternal polycystic ovary syndrome (PCOS) has potential detrimental effects on the neurodevelopment of offspring. This study aimed to evaluate the brain metrics in fetuses of women with PCOS based on fetal magnetic resonance imaging (MRI).MethodsThis retrospective study included 60 pregnant women with PCOS (PCOS group) and 120 pregnant non-PCOS women (control group). Fetal MRI was performed followed an ultrasound and for numerous clinical indications including known or suspected fetal pathology, history of fetal abnormality in previous pregnancy or in a family member. Fetal brain biometry and apparent diffusion coefficient (ADC) value were analysed.ResultsAfter adjusting for potential confounders, fetuses in the PCOS group showed the following characteristics compared to fetuses in the control group: (1) smaller cerebral fronto-occipital diameter (FOD), vermian height (VH) and anteroposterior diameter of the pons (APDP) (evident before 32 weeks;P = 0.042,P = 0.002 andP = 0.016, respectively); (2) larger left and right biparietal index (evident before 32 weeks;P = 0.048 andP = 0.025, respectively); (3) smaller left lateral ventricle (LV) (evident after 32 weeks;P = 0.005); (4) larger anteroposterior diameter of the vermis (APDV) and hippocampal infolding angle (HIA) (evident after 32 weeks;P = 0.003 andP 0.001, respectively); (5) higher ADC value in frontal white matter (FWM) and in basal ganglia (BG) (evident before and after 32 weeks; allP 0.05).ConclusionsThere exist a different pattern of brain metrics in PCOS offspringin utero.
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DOI：
10.1111/jcpp.13301
发表时间：
2021-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Norr ME;Hect JL;Lenniger CJ;Van den Heuvel M;Thomason ME
通讯作者：
Thomason ME
影响因子：
6.1
作者：
Belli, Griffith A.;Sundaram, Rajeshwari;Yeung, Edwina H.
通讯作者：
Yeung, Edwina H.
DOI：
10.3174/ajnr.a1309
发表时间：
2009-01
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Nguyen The Tich S;Anderson PJ;Shimony JS;Hunt RW;Doyle LW;Inder TE
通讯作者：
Inder TE
影响因子：
6.9
作者：
Cesta, Carolyn E.;Oberg, Anna S.;Rosenqvist, Mina A.
通讯作者：
Rosenqvist, Mina A.
影响因子：
16.2
作者：
Page, Kathleen A.;Luo, Shan;Xiang, Anny H.
通讯作者：
Xiang, Anny H.