An examination of maternal prenatal BMI and human fetal brain development.
An examination of maternal prenatal BMI and human fetal brain development.
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DOI：
10.1111/jcpp.13301
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Thomason ME
中科院分区：
文献类型：
--
作者：
Norr ME;Hect JL;Lenniger CJ;Van den Heuvel M;Thomason ME
产前发育是大脑极易受到环境因素（如毒素、孕产妇健康）的侮辱和改变的时期。一个重要的危险因素是母亲肥胖（身体质量指数bb30）。最近的研究表明，怀孕期间母亲的高BMI与后代一生中许多身体健康、认知和精神健康问题的风险增加有关。孕妇产前BMI指数的升高甚至可能在出生前就影响了发育中的大脑。本研究在人类胎儿大脑的宏观电路水平上考察了这种可能性。使用数据驱动策略将大脑分割成子网络，我们测试了109名年龄在26至39周之间的胎儿神经网络内部或之间的MRI功能连接是否随母体产前BMI变化。我们发现，左侧脑岛前部/额下回（aIN/ IFG）和双侧前额叶皮层（PFC）这两个子网络之间的连通性强度随着母亲的BMI而变化。在个体aIN/IFG-PFC连接水平上，我们观察到网络间连通性增加和减少，在高BMI妊娠中，半球内连通性增加和半球间连通性减少。根据基于网络的统计分析，母亲的BMI与网络地形的全球差异无关。总体影响局限于后来将支持行为调节和整合过程的区域，这些区域通常与肥胖相关的缺陷有关。通过建立出生前的神经差异，本研究支持了一个模型，即母体bmi相关风险与胎儿连接体水平的大脑组织相关，并对后代的长期认知发展和心理健康有影响。
Prenatal development is a time when the brain is acutely vulnerable to insult and alteration by environmental factors (e.g., toxins, maternal health). One important risk factor is maternal obesity (Body Mass Index > 30). Recent research indicates that high maternal BMI during pregnancy is associated with increased risk for numerous physical health, cognitive, and mental health problems in offspring across the lifespan. It is possible that heightened maternal prenatal BMI influences the developing brain even before birth. The present study examines this possibility at the level of macrocircuitry in the human fetal brain. Using a data-driven strategy for parcellating the brain into subnetworks, we test whether MRI functional connectivity within or between fetal neural subnetworks varies with maternal prenatal BMI in 109 fetuses between the ages of 26 and 39weeks. We discovered that strength of connectivity between two subnetworks, left anterior insula/inferior frontal gyrus (aIN/ IFG) and bilateral prefrontal cortex (PFC), varied with maternal BMI. At the level of individual aIN/IFG-PFC connections, we observed both increased and decreased between-network connectivity with a tendency for increased within-hemisphere connectivity and reduced cross-hemisphere connectivity in higher BMI pregnancies. Maternal BMI was not associated with global differences in network topography based on network-based statistical analyses. Overall effects were localized in regions that will later support behavioral regulation and integrative processes, regions commonly associated with obesity-related deficits. By establishing onset in neural differences prior to birth, this study supports a model in which maternal BMI-related risk is associated with fetal connectome-level brain organization with implications for offspring long-term cognitive development and mental health.
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发表时间：
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影响因子：
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