Epigenetic modifications in cancer.
Epigenetic modifications in cancer.
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DOI：
10.1111/j.1399-0004.2011.01809.x
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发表时间：
2012-04
影响因子：
3.5
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Kanwal R;Gupta S
癌症的发生和发展是由遗传和表观遗传事件控制的。癌变的复杂性不能单靠基因改变来解释，还涉及到表观遗传变化。表观遗传学是指在不改变原始DNA序列的情况下改变基因表达的机制的研究。表观遗传机制是可遗传和可逆的，包括DNA甲基化、组蛋白修饰和小非编码microrna （miRNA）的变化。表观遗传过程的破坏可导致基因功能改变和恶性细胞转化。异常的表观遗传修饰可能发生在肿瘤发展的早期阶段，它们被广泛描述为癌症进展的重要参与者。表观遗传学的最新进展使我们更好地理解了癌症发生的潜在机制，并为发现用于早期检测、疾病监测、预后和风险评估的推定癌症生物标志物提供了见解。在这篇综述中，我们总结了目前关于表观遗传改变引起的遗传改变被认为是导致癌症的文献，并讨论了表观遗传学未来研究的潜在影响。
Cancer initiation and progression is controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot be accounted for by genetic alterations alone but also involves epigenetic changes. Epigenetics refers to the study of mechanisms that alter gene expression without altering the primary DNA sequence. Epigenetic mechanisms are heritable and reversible, and include changes in DNA methylation, histone modifications and small noncoding microRNAs (miRNA). Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Aberrant epigenetic modifications probably occur at a very early stage in neoplastic development, and they are widely described as essential players in cancer progression. Recent advances in epigenetics offer a better understanding of the underlying mechanism(s) of carcinogenesis and provide insight into the discovery of putative cancer biomarkers for early detection, disease monitoring, prognosis, and risk assessment. In this review, we summarize the current literature on epigenetic changes causing genetic alterations that are thought to contribute to cancer, and discuss the potential impact of epigenetics future research.
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影响因子：
--
作者：
Cui H
通讯作者：
Cui H
影响因子：
11.2
作者：
Bacolod MD;Schemmann GS;Giardina SF;Paty P;Notterman DA;Barany F
通讯作者：
Barany F
影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
影响因子：
14.9
作者：
Deplus, R;Brenner, C;Fuks, F
通讯作者：
Fuks, F
影响因子：
--
作者：
Cheung, Hoi-Hung;Lee, Tin-Lap;Rennert, Owen M.;Chan, Wai-Yee
通讯作者：
Chan, Wai-Yee