Demographic and Clinical Factors Associated with Patient-Reported Remission in Psoriasis.
Demographic and Clinical Factors Associated with Patient-Reported Remission in Psoriasis.
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DOI：
10.1007/s13555-022-00692-3
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Liao W
中科院分区：
文献类型：
--
作者：
Gondo G;Hadeler E;Brownstone N;Maverakis E;Merola JF;Armstrong AW;Bhutani T;Bell SJ;Liao W
银屑病的缓解是患者和提供者的关键目标，但缓解的定义可能会有所不同。一些治疗银屑病的目标举措侧重于皮肤受累程度，而另一些则纳入了生活质量（QoL）指标。本研究的目的是确定与患者报告的银屑病缓解相关的因素。国家银屑病基金会对美国1570名银屑病患者进行了随机分层抽样调查。该调查包含关于银屑病和/或银屑病关节炎的提供者诊断以及共病状况和参与者人口统计学的问题。使用患者银屑病累及程度报告（PREPI）评估银屑病严重程度，PREPI是一种经验证的体表面积（BSA）自我报告测量方法。使用皮肤病生活质量指数（DLQI）评估皮肤病相关生活质量。报告BSA ≤ 3%的个体被问及他们是否认为他们的银屑病处于缓解期。采用多因素logistic回归分析确定与缓解相关的因素。在报告BSA ≤ 3%的930名参与者中，479名（51.7%）认为他们的银屑病处于缓解期，平均缓解持续时间为31个月。在缓解期患者中，79.1%报告了当前治疗。多变量回归分析显示，银屑病缓解与女性、BSA较低、皮肤病生活质量指数和总体QoL受损较少、生物制品使用和银屑病关节炎合并诊断独立相关。与年龄、种族、体重指数或合并症数量无关。总体而言，患者对银屑病缓解的感知不仅与BSA相关，还与性别、生活质量和治疗类型相关。
Achievement of remission in psoriasis is a key goal for patients and providers, yet definitions of remission may vary. Some treat-to-target initiatives in psoriasis have focused on degree of skin involvement, while others have also incorporated quality of life (QoL) measures. The goal of this study is to identify factors associated with patient-reported psoriasis remission. The National Psoriasis Foundation conducted a survey of a random stratified sample of 1570 individuals with psoriatic disease in the USA. The survey contained questions regarding provider diagnosis of psoriasis and/or psoriatic arthritis, as well as comorbid conditions and participant demographics. Psoriasis severity was assessed using the Patient Report of Extent of Psoriasis Involvement (PREPI), a validated self-reported measure of body surface area (BSA). Dermatologic-related quality of life was assessed using the Dermatology Life Quality Index (DLQI). Individuals reporting BSA ≤ 3% were asked if they believed their psoriasis was in remission. Multivariate logistic regression was used to identify factors associated with remission. Of 930 participants reporting BSA ≤ 3%, 479 (51.7%) believed their psoriasis was in remission, with an average remission duration of 31 months. Of those in remission, 79.1% reported current treatment. Multivariate regression revealed that psoriasis remission was independently associated with female sex, lower BSA, less impairment in the Dermatology Life Quality Index and global QoL, biologic use, and concomitant diagnosis of psoriatic arthritis. There was no association with age, race, body mass index, or number of comorbidities. Overall, patient perception of psoriasis remission was not solely associated with BSA, but also with sex, quality of life, and treatment type.
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影响因子：
10.3
作者：
Dommasch, E. D.;Shin, D. B.;Gelfand, J. M.
通讯作者：
Gelfand, J. M.
影响因子：
13.8
作者：
Armstrong, April W.;Siegel, Michael P.;Van Voorhees, Abby S.
通讯作者：
Van Voorhees, Abby S.
影响因子：
14.2
作者：
Noda, Shinji;Krueger, James G.;Guttman-Yassky, Emma
通讯作者：
Guttman-Yassky, Emma
影响因子：
3.7
作者：
Stumpf A;Burgmer M;Schneider G;Heuft G;Schmelz M;Phan NQ;Ständer S;Pfleiderer B
通讯作者：
Pfleiderer B
影响因子：
4.1
作者：
FINLAY, AY;KHAN, GK
通讯作者：
KHAN, GK