Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women.
Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women.
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DOI：
10.1093/gerona/gln018
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Semba RD
中科院分区：
文献类型：
--
作者：
Dalal M;Ferrucci L;Sun K;Beck J;Fried LP;Semba RD
晚期糖基化终产物（AGEs）与糖尿病、心脏病和肾衰竭的发病机制有关，并可能影响骨骼肌。AGEs是否与肌肉力量差有关尚不清楚。在马里兰州的巴尔的摩进行的妇女健康与衰老研究I中，对559名年龄≥65岁的中度至重度残疾妇女的血清羧甲基赖氨酸（CML）（一种主要AGE）、AGE循环受体（sIgE）、内源性分泌型赖氨酸（esIgE）和握力进行了测定。血清CML最高四分位数女性与较低三个四分位数女性的平均（SD）握力分别为18.6和20.0公斤（P = 0.002），调整了年龄、种族、体重指数、认知功能障碍、抑郁症和糖尿病。血清睾酮和雌二醇与握力无显著相关性。血清AGEs水平高的女性有更大的肌无力。需要进一步的研究来确定AGEs，一个潜在的可改变的风险因素，是否与老年人的身体表现和残疾有关。
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes, heart disease, and kidney failure, and may potential affect skeletal muscle. Whether AGEs are associated with poor muscle strength is unknown. Serum carboxymethyl-lysine (CML), a dominant AGE, circulating receptor for AGEs (sRAGE), and endogenous secretory RAGE (esRAGE) and grip strength were measured in 559 moderately to severely disabled women, age ≥65 years, in the Women’s Health and Aging Study I in Baltimore, Maryland. Mean (SD) grip strength among women in the highest quartile of serum CML compared with women in the lower three quartiles was 18.6 and 20.0 kg, respectively (P = 0.002), adjusting for age, race, body mass index, cognitive dysfunction, depression, and diabetes. Serum sRAGE and esRAGE were not significantly associated with grip strength. Women with high serum AGEs have greater muscle weakness. Further studies are needed to determine whether AGEs, a potentially modifiable risk factor, are associated with physical performance and disability in older adults.
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影响因子：
6
作者：
Beck, Justine;Ferrucci, Luigi;Semba, Richard D.
通讯作者：
Semba, Richard D.
影响因子：
8
作者：
Nakamura, Kazuo;Yamagishi, Sho-ichi;Imaizumi, Tsutomu
通讯作者：
Imaizumi, Tsutomu
影响因子：
--
作者：
Goldberg, T;Cai, WJ;Vlassara, H
通讯作者：
Vlassara, H
影响因子：
6.9
作者：
Guallar-Castillon, Pilar;Sagardui-Villamor, Jon;Rodriguez-Artalejo, Fernando
通讯作者：
Rodriguez-Artalejo, Fernando
影响因子：
120.7
作者：
Rantanen, T;Guralnik, JM;White, L
通讯作者：
White, L