'Bouncing Back' From Subclinical Malaria: Inflammation and Erythrocytosis After Resolution of P. falciparum Infection in Gambian Children.
'Bouncing Back' From Subclinical Malaria: Inflammation and Erythrocytosis After Resolution of P. falciparum Infection in Gambian Children.
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亚临床疟疾的“反弹”：冈比亚儿童的恶性疟原虫感染后的炎症和红细胞增多症。
DOI：
10.3389/fimmu.2022.780525
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发表时间：
2022
影响因子：
7.3
通讯作者：
Riley EM
中科院分区：
文献类型：
--
作者：
Mooney JP;DonVito SM;Jahateh M;Bittaye H;Keith M;Galloway LJ;Ndow M;Cunnington AJ;D'Alessandro U;Bottomley C;Riley EM
最近的疟疾与全身性细菌感染的风险增加有关。这种关联的病因尚不清楚，但疟疾相关的溶血可能是一个促成因素。为了确定持续和最近解决的疟疾感染和相关溶血的生理后果，在每年的疟疾传播季节结束时（t1），对1650名8-15岁的健康冈比亚儿童进行了恶性疟原虫感染（通过18 sRNA PCR）和/或贫血（通过红细胞压积）筛查。将感染恶性疟原虫的儿童和患有中度或重度贫血（血红蛋白浓度<11 g/dl）的儿童与健康、未感染、非贫血的对照组进行年龄匹配，并在2个月后（t2）再次进行筛查。持续感染的儿童（PCR阳性，在t1和t2）有稳定的寄生虫负担，并没有显着不同的血液学或促炎标志物从健康，未感染的儿童。然而，在持续感染的儿童中，IL-10浓度与寄生虫密度呈正相关，表明对持续感染的耐受性反应。相比之下，自然解决感染的儿童（t1时阳性，t2时阴性）表现出轻度红细胞增多，与其他儿童组相比，促炎标志物的浓度升高。这些发现揭示了疟疾感染后的稳态血液反应的“重置”和潜在的超调。有趣的是，在未感染儿童中测试的大多数参数高度异质，这表明有些儿童可能患有隐性疟疾或其他感染。
Recent malaria is associated with an increased risk of systemic bacterial infection. The aetiology of this association is unclear but malaria-related haemolysis may be one contributory factor. To characterise the physiological consequences of persistent and recently resolved malaria infections and associated haemolysis, 1650 healthy Gambian children aged 8–15 years were screened for P. falciparum infection (by 18sRNA PCR) and/or anaemia (by haematocrit) at the end of the annual malaria transmission season (t1). P. falciparum-infected children and children with moderate or severe anaemia (haemoglobin concentration < 11g/dl) were age matched to healthy, uninfected, non-anaemic controls and screened again 2 months later (t2). Persistently infected children (PCR positive at t1 and t2) had stable parasite burdens and did not differ significantly haematologically or in terms of proinflammatory markers from healthy, uninfected children. However, among persistently infected children, IL-10 concentrations were positively correlated with parasite density suggesting a tolerogenic response to persistent infection. By contrast, children who naturally resolved their infections (positive at t1 and negative at t2) exhibited mild erythrocytosis and concentrations of pro-inflammatory markers were raised compared to other groups of children. These findings shed light on a ‘resetting’ and potential overshoot of the homeostatic haematological response following resolution of malaria infection. Interestingly, the majority of parameters tested were highly heterogeneous in uninfected children, suggesting that some may be harbouring cryptic malaria or other infections.
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影响因子：
15.8
作者：
Chen I;Clarke SE;Gosling R;Hamainza B;Killeen G;Magill A;O'Meara W;Price RN;Riley EM
通讯作者：
Riley EM
DOI：
10.1016/s1473-3099(21)00072-4
发表时间：
2021-11
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Andolina C;Rek JC;Briggs J;Okoth J;Musiime A;Ramjith J;Teyssier N;Conrad M;Nankabirwa JI;Lanke K;Rodriguez-Barraquer I;Meerstein-Kessel L;Arinaitwe E;Olwoch P;Rosenthal PJ;Kamya MR;Dorsey G;Greenhouse B;Drakeley C;Staedke SG;Bousema T
通讯作者：
Bousema T
影响因子：
5.2
作者：
Frimpong A;Amponsah J;Adjokatseh AS;Agyemang D;Bentum-Ennin L;Ofori EA;Kyei-Baafour E;Akyea-Mensah K;Adu B;Mensah GI;Amoah LE;Kusi KA
通讯作者：
Kusi KA
影响因子：
16.6
作者：
Barry A;Bradley J;Stone W;Guelbeogo MW;Lanke K;Ouedraogo A;Soulama I;Nébié I;Serme SS;Grignard L;Patterson C;Wu L;Briggs JJ;Janson O;Awandu SS;Ouedraogo M;Tarama CW;Kargougou D;Zongo S;Sirima SB;Marti M;Drakeley C;Tiono AB;Bousema T
通讯作者：
Bousema T
影响因子：
3
作者：
Mooney JP;Barry A;Gonçalves BP;Tiono AB;Awandu SS;Grignard L;Drakeley CJ;Bottomley C;Bousema T;Riley EM
通讯作者：
Riley EM