Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.
Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.
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DOI：
10.1038/s41467-021-22573-7
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发表时间：
2021-04-26
影响因子：
16.6
通讯作者：
Bousema T
中科院分区：
文献类型：
--
作者：
Barry A;Bradley J;Stone W;Guelbeogo MW;Lanke K;Ouedraogo A;Soulama I;Nébié I;Serme SS;Grignard L;Patterson C;Wu L;Briggs JJ;Janson O;Awandu SS;Ouedraogo M;Tarama CW;Kargougou D;Zongo S;Sirima SB;Marti M;Drakeley C;Tiono AB;Bousema T
恶性疟原虫配子体动力学和感染性在慢性感染和偶发感染之间可能不同。在目前的研究中，我们评估了布基纳法索儿童（5-10岁）的寄生虫动力学和对蚊子的传染性，其中：(a)寄生虫清除后的偶发感染（n = 48）和(b)慢性无症状感染（n = 60）。在偶发性感染队列中，92%（44/48）的儿童在35天内出现症状，而在慢性队列中为23%（14/60）。所有慢性感染患者均携带配子细胞或在随访期间产生配子细胞，而在出现症状并接受治疗前，只有35%（17/48）的患者产生配子细胞。寄生虫的增殖率（PMR）和ap2-g和gexp-5转录本的相对丰度与配子体的产生呈正相关。慢性感染的抗体反应较高，PMR较低。症状和性阶段免疫反应的出现与配子细胞对蚊子的感染性降低有关。我们观察到，大多数偶发感染需要在成熟配子体密度足以感染蚊子之前进行治疗。相反，慢性无症状感染是蚊子感染的一个重要来源。我们的观察结果支持这样一种观点，即通过加强病例管理，包括症状筛查和感染检测，可以加速减少疟疾传播。在这项对布基纳法索儿童恶性疟原虫感染事件（新发感染）和慢性（无症状感染）队列的纵向研究中，作者发现慢性感染的配子体细胞产量和蚊子传染性更高。
Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and incident infections. In the current study, we assess parasite kinetics and infectivity to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) incident infections following parasite clearance (n = 48) and (b) chronic asymptomatic infections (n = 60). In the incident infection cohort, 92% (44/48) of children develop symptoms within 35 days, compared to 23% (14/60) in the chronic cohort. All individuals with chronic infection carried gametocytes or developed them during follow-up, whereas only 35% (17/48) in the incident cohort produce gametocytes before becoming symptomatic and receiving treatment. Parasite multiplication rate (PMR) and the relative abundance of ap2-g and gexp-5 transcripts are positively associated with gametocyte production. Antibody responses are higher and PMR lower in chronic infections. The presence of symptoms and sexual stage immune responses are associated with reductions in gametocyte infectivity to mosquitoes. We observe that most incident infections require treatment before the density of mature gametocytes is sufficient to infect mosquitoes. In contrast, chronic, asymptomatic infections represent a significant source of mosquito infections. Our observations support the notion that malaria transmission reduction may be expedited by enhanced case management, involving both symptom-screening and infection detection. In this longitudinal study of an incident (new infections) and chronic (asymptomatic infections) cohort of Plasmodium falciparum infection in children in Burkina Faso, the authors show higher gametocyte production and mosquito infectivity in chronic infections.
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影响因子：
--
作者：
Barry, Aissata;Behet, Marije C;Goncalves, Bronner P
通讯作者：
Goncalves, Bronner P
DOI：
10.4269/ajtmh.1992.46.711
发表时间：
1992-06-01
影响因子：
3.3
作者：
GRAVES, PM;DOUBROVSKY, A;BATTISTUTTA, D
通讯作者：
BATTISTUTTA, D
影响因子：
4.6
作者：
Hjerrild KA;Jin J;Wright KE;Brown RE;Marshall JM;Labbé GM;Silk SE;Cherry CJ;Clemmensen SB;Jørgensen T;Illingworth JJ;Alanine DG;Milne KH;Ashfield R;de Jongh WA;Douglas AD;Higgins MK;Draper SJ
通讯作者：
Draper SJ
影响因子：
7.7
作者：
Bradley, John;Stone, Will;Bousema, Teun
通讯作者：
Bousema, Teun
影响因子：
2.9
作者：
Collins, Katharine A.;Ouedraogo, Alphonse;Tiono, Alfred
通讯作者：
Tiono, Alfred