Heart Development and Regeneration in Non-mammalian Model Organisms.
Heart Development and Regeneration in Non-mammalian Model Organisms.
复制标题
非哺乳动物模型生物体的心脏发育和再生
DOI：
10.3389/fcell.2020.595488
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Xia J;Meng Z;Ruan H;Yin W;Xu Y;Zhang T
心血管疾病是对人类健康的严重威胁，也是全世界死亡的主要原因。近年来，在心脏形成和发育的理解方面取得了令人兴奋的进展，使心脏生物学家在治疗性心脏再生领域取得了重大进展。我们对心脏发育和再生的大部分理解，包括基因和信号通路，都是由非哺乳动物模式生物的开创性工作驱动的，如果蝇，鱼，青蛙和鸡。与哺乳动物模型相比，非哺乳动物模型生物在疾病建模、药物发现和心脏毒性筛选等高通量应用中具有特殊的优势。心血管疾病的基因工程动物为研究发病机制的分子和细胞机制以及评估治疗策略提供了有价值的工具。大量的先天性心脏病（CHD）非哺乳动物模型已经建立并检测了与疾病相关的基因和信号通路。在此，我们回顾了这些模型揭示的心脏发育和再生的机制，强调了非哺乳动物模型作为心脏研究工具的优势。这些动物模型的知识将促进治疗发现，并最终有助于加速转化医学。
Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant advance in the field of therapeutic heart regeneration. Most of our understanding of heart development and regeneration, including the genes and signaling pathways, are driven by pioneering works in non-mammalian model organisms, such as fruit fly, fish, frog, and chicken. Compared to mammalian animal models, non-mammalian model organisms have special advantages in high-throughput applications such as disease modeling, drug discovery, and cardiotoxicity screening. Genetically engineered animals of cardiovascular diseases provide valuable tools to investigate the molecular and cellular mechanisms of pathogenesis and to evaluate therapeutic strategies. A large number of congenital heart diseases (CHDs) non-mammalian models have been established and tested for the genes and signaling pathways involved in the diseases. Here, we reviewed the mechanisms of heart development and regeneration revealed by these models, highlighting the advantages of non-mammalian models as tools for cardiac research. The knowledge from these animal models will facilitate therapeutic discoveries and ultimately serve to accelerate translational medicine.
DOI：
10.5713/ajas.2012.12626
发表时间：
2013-04
期刊：
Asian-Australasian journal of animal sciences
影响因子：
--
作者：
Ban Q;Liu X;Hui W;Chen D;Zhao Z;Jia B
通讯作者：
Jia B
影响因子：
7.5
作者：
Liao S;Dong W;Zhao H;Huang R;Qi X;Cai D
通讯作者：
Cai D