Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems.
Cardiac regeneration in Xenopus tropicalis and Xenopus laevis: discrepancies and problems.
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DOI：
10.1186/s13578-018-0230-6
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发表时间：
2018
影响因子：
7.5
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Liao S;Dong W;Zhao H;Huang R;Qi X;Cai D
最近有两项研究重点关注非洲爪蟾成年心脏再生。虽然我们报道了热带爪蟾受伤后的心肌再生，但马歇尔和同事发现非洲爪蟾受伤的心脏没有再生。在此，我们想加入Marshall等人发起的讨论。谁对这两项研究中的方法和物种差异进行了争论。我们同意他们的观点，即心脏再生能力的物种差异可能导致这两项研究的结果不同。此外，我们认为这些研究中使用的动物的年龄可能会导致再生的差异。 5 年生的 X. laevis 比 1 年生的 X.tropicalis 年龄要大得多。差异的另一个原因可能是凝块的大小。由于切除方案不同，Marshall等人进行内镜切除后形成了血栓。比我们研究中使用的传统切除后的尺寸大得多。此外，受伤部位的差异可能会影响愈合和再生的差异。需要详细检查生物年龄、诱导损伤的技术和损伤部位对再生的影响，以评估两栖动物心脏的再生潜力。
Two studies have recently focused on adult heart regeneration in Xenopus. While we reported on cardiac myogenic regeneration in Xenopus tropicalis after injury, Marshall and colleagues found no regeneration in an injured heart in Xenopus laevis. Here, we would like to join the discussion initiated by Marshall et al. who debated the methods and species differences in both studies. We agree with their view that the species difference in cardiac regenerative capacity could lead to different results in both of these studies. Moreover, we suggest that the age of the animals used in these studies could lead to differences in regeneration. A 5-year old X. laevis is much more advanced in age than a 1-year old X. tropicalis. The other reason for the discrepancies could be the size of the clot. Due to different resection protocols, the clot formed after the endoscopic resection performed by Marshall et al. was much larger than that after a conventional resection, as used in our study. Furthermore, the difference in the site of injury could influence the healing and regeneration differences. The influence of the organismal age, techniques used to induce injury and site of injury on regeneration need to be examined in detail to assess the regenerative potential of the amphibian heart.
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影响因子：
3.6
作者：
Franchini, Antonella;Bertolotti, Evelina
通讯作者：
Bertolotti, Evelina
影响因子：
7.5
作者：
Liao S;Dong W;Lv L;Guo H;Yang J;Zhao H;Huang R;Yuan Z;Chen Y;Feng S;Zheng X;Huang J;Huang W;Qi X;Cai D
通讯作者：
Cai D
心肌梗死时心肌细胞减少及其对大鼠缺血性心脏的治疗作用
影响因子：
5.3
作者：
Zhao B;Chen S;Liu J;Yuan Z;Qi X;Qin J;Zheng X;Shen X;Yu Y;Qnin TJ;Chan JY;Cai D
通讯作者：
Cai D
影响因子：
3.7
作者：
Marshall L;Vivien C;Girardot F;Péricard L;Demeneix BA;Coen L;Chai N
通讯作者：
Chai N
DOI：
10.1073/pnas.0600635103
发表时间：
2006-06-13
影响因子：
11.1
作者：
Urbanek, Konrad;Cesselli, Daniela;Leri, Annarosa
通讯作者：
Leri, Annarosa