Liver involvement in subjects with rheumatic disease.

Liver involvement in subjects with rheumatic disease.
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DOI:
10.1186/ar3319
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发表时间:
2011-06-30
影响因子:
4.9
通讯作者:
Gershwin ME
Gershwin ME
中科院分区:
医学2区
文献类型:
--
作者:
Selmi C;De Santis M;Gershwin ME

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肝脏作为靶器官经常被忽视,病理学要么继发于基础疾病,要么是由于治疗的毒性和肝外疾病的医学并发症。因此,重要的是临床流变学家要知道诊断程序,以监测肝损伤。事实上,全身性风湿性疾病可能与继发于共存自身免疫性肝病(特别是原发性胆汁性肝硬化或自身免疫性肝炎)、肝实质直接受累或药物治疗(特别是甲氨蝶呤)对肝脏的影响的肝脏异常相关。此外,风湿科医生应了解免疫抑制剂对潜在病毒感染,特别是病毒性肝炎的影响。我们在此回顾了肝脏在全身性风湿性疾病临床治疗中的作用。
The liver is often overlooked as a target organ, with pathology either secondary to an underlying disease or due to the toxicity of therapies and the medical complications of extrahepatic diseases. It is thus important for the clinical rheumatologist to be aware of the diagnostic procedure to monitor liver injury. Indeed, systemic rheumatologic diseases may be associated with liver abnormalities secondary to the presence of a coexisting autoimmune liver disease (particularly primary biliary cirrhosis or autoimmune hepatitis), the direct involvement of the liver parenchyma, or the impact of medical treatments (particularly methotrexate) on the liver. In addition, the rheumatologist should be aware of the impact of immunosuppressive agents on underlying viral infections, particularly viral hepatitis. We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases.
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期刊: The Journal of rheumatology
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