Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients.
Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients.
复制标题
DOI：
10.3899/jrheum.090340
复制
发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Mayes MD
中科院分区：
文献类型：
--
作者：
Assassi S;Fritzler MJ;Arnett FC;Norman GL;Shah KR;Gourh P;Manek N;Perry M;Ganesh D;Rahbar MH;Mayes MD
研究抗线粒体抗体（AMA）、sp100和gp 210抗体在大量系统性硬化症（SSc）患者中诊断原发性胆汁性肝硬化（PBC）的准确性;检查这些抗体与SSc亚群的一致性。此外，评估Ssc相关抗体与肝脏参数异常的相关性。我们获得了医疗记录，以验证SSc和PBC的诊断。检查所有参与者的血清中是否存在SSc和PBC相关抗体，以及肝脏参数是否异常。我们检查了817例SSc患者，其中16例（2%）确诊为PBC。MIT 3 ELISA检测AMA的敏感性和特异性分别为81.3%和94.6%。Sp100的敏感性和特异性分别为31.3%和97.4%，而gp 210的敏感性更低。我们能够使用AMA（MIT 3）和sp100作为联合标志物检测所有PBC病例，导致灵敏度显著提高至100%（p = 0.042），特异性逐渐降低至92.6%。独立于AMA或sp100状态，抗着丝粒B（CENP-B）和抗拓扑异构酶抗体（ATA）与较高的碱性磷酸酶水平相关（分别为p = 0.051和p = 0.003），而抗RNA聚合酶III（抗RNAP）与较低的碱性磷酸酶水平相关（p = 0.019）。利用AMA（MIT 3）和sp100抗体作为联合诊断标志物，可改善SSc患者PBC的检测。CENP-B和ATA与碱性磷酸酶升高相关。
To investigate the diagnostic accuracy of antimitochondrial antibodies (AMA), sp100, and gp210 antibodies for primary biliary cirrhosis (PBC) in a large population of patients with systemic sclerosis (SSc); to examine concordance of these antibodies with subsets of SSc. Further, to assess the association of SSc-related antibodies with hepatic parameter abnormalities. We obtained medical records to verify the diagnoses of SSc and PBC. Sera from all participants were examined for the presence of SSc- and PBC-related antibodies, as well as for abnormalities in hepatic parameters. We examined 817 patients with SSc, of whom 16 (2%) had confirmed PBC. The sensitivity and specificity of AMA by a MIT3 ELISA for PBC were 81.3% and 94.6%, respectively. Sp100 had a sensitivity and specificity of 31.3% and 97.4%, respectively, while gp210 had an even lower sensitivity. We were able to detect all PBC cases using AMA(MIT3) and sp100 as a combined marker, resulting in a significantly improved sensitivity of 100% (p = 0.042) with an incremental decrease in specificity to 92.6%. Independent of AMA or sp100 status, there was an association of anticentromere B (CENP-B) and anti-topoisomerase antibodies (ATA) with higher alkaline phosphatase levels (p = 0.051 and p = 0.003, respectively) while anti-RNA polymerase III (anti-RNAP) was associated with lower alkaline phosphatase levels (p = 0.019) among the patients with SSc. Utilization of AMA(MIT3) and sp100 antibodies as a combined diagnostic marker leads to an improved detection of PBC in patients with SSc. CENP-B and ATA are associated with alkaline phosphatase elevation.
登录
查看更多内容
影响因子：
13.5
作者：
Nakamura, Minoru;Kondo, Hisayoshi;Ishibashi, Hiromi
通讯作者：
Ishibashi, Hiromi
DOI：
10.1111/j.1440-1746.1998.01553.x
发表时间：
1998-03-01
影响因子：
4.1
作者：
Itoh, S;Ichida, T;Asakura, H
通讯作者：
Asakura, H
影响因子：
5
作者：
Arnett, F C
通讯作者：
Arnett, F C
影响因子：
--
作者：
EVANS, J;REUBEN, A;CRAFT, J
通讯作者：
CRAFT, J
影响因子：
29.4
作者：
LASSOUED, K;BRENARD, R;BENHAMOU, JP
通讯作者：
BENHAMOU, JP