(18)F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques.
(18)F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques.
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DOI：
10.1007/s12350-018-1325-5
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发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Mulder DJ
中科院分区：
文献类型：
--
作者：
Hop H;de Boer SA;Reijrink M;Kamphuisen PW;de Borst MH;Pol RA;Zeebregts CJ;Hillebrands JL;Slart RHJA;Boersma HH;Doorduin J;Mulder DJ
18F-NaF正电子发射断层扫描(PET)的目标是微钙化。我们比较了体外microPET评估罪犯和非罪犯颈动脉斑块对18F-NaF的摄取。此外，我们将18F-NaF摄取与显微计算机断层扫描(MicroCT)显示的钙化进行了比较。接受手术的中风患者的颈动脉斑块在18F-NaF中孵育，并使用microPET和microCT扫描。PET评估的平均18F-NaF摄取量以每克孵化剂量的百分比(%InC/g)表示。将18F-NaF PET感兴趣体积(VOI)与CT钙化VOI进行比较。颈动脉斑块23例(肇事者17例，非肇事者6例)。罪犯颈动脉斑块的平均18F-NaF摄取与非罪犯颈动脉斑块的摄取相当(中位数2.32%InC/g[IQR1.98~2.81]vs.2.35%InC/g[IQR1.77~3.00]，P = 0.916)。仅10%(IQR4~25)的CT钙化VOI显示18F-NaF摄取增加，而18F-NaF PET VOI在CT上显示钙化的中位数仅为35%(IQR6~42)。18F-NaF-PET代表了与CT不同的钙化过程阶段。我们在高危患者的罪犯和非罪犯斑块中观察到类似的PET评估18F-NaF的摄取和模式，表明该方法在动脉粥样硬化性狭窄的早期发展中可能更有价值。这篇文章的在线版本(10.1007/s12350-018-第1325-5)载有补充材料，授权用户可以使用。
18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT). Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI. 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT. 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development. The online version of this article (10.1007/s12350-018-1325-5) contains supplementary material, which is available to authorized users.
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影响因子：
4.4
作者：
Hutcheson JD;Maldonado N;Aikawa E
通讯作者：
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