Annotation: parathyroid hormone and fracture healing.

Annotation: parathyroid hormone and fracture healing.
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DOI:
10.3109/17453674.2013.771301
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发表时间:
2013-02
期刊:
影响因子:
3.7
通讯作者:
Aspenberg P
Aspenberg P
中科院分区:
医学2区
文献类型:
--
作者:
Aspenberg P

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这一注释描述了一些早期的大鼠研究,这些研究得出结论:甲状旁腺激素(PTH)对骨修复的刺激作用比对未受创伤的骨更显著。基于甲状旁腺激素对成骨细胞的影响,它还表明,它更有可能促进正常骨折的愈合,而不是防止骨不连。仅有的2个已发表的对照临床试验进行了批判性讨论。虽然这两种方法都令人鼓舞,而且似乎显示加速了正常的骨折愈合,但它们都存在方法学上的缺陷,无法得出明确的结论。
This annotation describes some early rat studies which conclude that parathyroid hormone (PTH) has more dramatic stimulatory effects on bone repair than on untraumatized bone. It also suggests, based on the effects of PTH on osteoblasts, that it is more likely to accelerate normal fracture healing than to prevent non-union. The only 2 controlled clinical trials that have been published are critically discussed. Although both are encouraging and appear to show acceleration of normal fracture healing, they have methodological shortcomings that preclude definitive conclusions.
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