Experimental hookworm infection: a randomized placebo-controlled trial in asthma.
Experimental hookworm infection: a randomized placebo-controlled trial in asthma.
复制标题
DOI：
10.1111/j.1365-2222.2009.03433.x
复制
发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Britton JR
中科院分区：
文献类型：
--
作者：
Feary JR;Venn AJ;Mortimer K;Brown AP;Hooi D;Falcone FH;Pritchard DI;Britton JR
流行病学研究表明，钩虫感染可以预防哮喘，因此钩虫感染可能对该疾病具有直接或间接的治疗潜力。我们现在报告第一个针对过敏性哮喘患者的实验性钩虫感染的临床试验。确定实验性钩虫感染对哮喘的影响。 32 名患有哮喘且对单磷酸腺苷 (AMP) 具有可测量气道反应性的个体被随机分组并双盲，接受 10 只美洲板口线虫幼虫或组胺溶液（安慰剂）的皮肤给药，并随访 16 周。主要结局是从基线到第 16 周，将 1 秒内用力呼气量减少 20% (PD20AMP) 所需的吸入 AMP 激发剂量的变化。次要结局包括哮喘控制和过敏原皮肤敏感性的多项措施的变化以及不良反应的发生。两组的平均 PD20AMP 均有所改善，钩虫组 [1.49 双倍剂量 (DD)] 比安慰剂组 (0.98 DD) 改善更多，但组间差异并不显着 (0.51 DD；95% 置信区间：-1.79 至 2.80；P=0.65)。两组之间哮喘控制或过敏原皮肤致敏的其他措施没有显着差异。感染通常具有良好的耐受性。在本研究中，用十只钩虫幼虫感染哮喘并没有导致支气管反应性或其他哮喘控制措施的显着改善。然而，感染的耐受性良好，并且导致气道反应性无显着改善，这表明更接近自然感染的进一步研究是可行的，并且应该进行。引用：J. R. Feary、A. J. Venn、K. Mortimer、A. P Brown、D. Hooi、F. H. Falcone、D. I. Pritchard 和 J. R. Britton，临床与实验过敏，2010 (40) 299–306。
Epidemiological studies suggest that hookworm infection protects against asthma, and therefore that hookworm infection may have a direct or an indirect therapeutic potential in this disease. We now report the first clinical trial of experimental hookworm infection in people with allergic asthma. To determine the effects of experimental hookworm infection in asthma. Thirty-two individuals with asthma and measurable airway responsiveness to adenosine monophosphate (AMP) were randomized and double blinded to cutaneous administration of either ten Necator americanus larvae, or histamine solution (placebo), and followed for 16 weeks. The primary outcome was the change in provocation dose of inhaled AMP required to reduce forced expiratory volume in 1 s by 20% (PD20AMP) from baseline to week 16. Secondary outcomes included change in several measures of asthma control and allergen skin sensitivity and the occurrence of adverse effects. Mean PD20AMP improved in both groups, more in the hookworm [1.49 doubling doses (DD)] than the placebo group (0.98 DD), but the difference between groups was not significant (0.51 DD; 95% confidence interval: −1.79 to 2.80; P=0.65). There were no significant differences between the two groups for other measures of asthma control or allergen skin sensitization. Infection was generally well tolerated. Experimental infection with ten hookworm larvae in asthma did not result in significant improvement in bronchial responsiveness or other measures of asthma control in this study. However, infection was well tolerated and resulted in a non-significant improvement in airway responsiveness, indicating that further studies that mimic more closely natural infection are feasible and should be undertaken. Cite this as: J. R. Feary, A. J. Venn, K. Mortimer, A. P Brown, D. Hooi, F. H. Falcone, D. I. Pritchard and J. R. Britton, Clinical & Experimental Allergy, 2010 (40) 299– 306.
登录
查看更多内容
影响因子：
2.2
作者：
PRITCHARD, DI;QUINNELL, RJ;WALSH, EA
通讯作者：
WALSH, EA
影响因子：
168.9
作者：
Scrivener, S;Yemaneberhan, H;Britton, J
通讯作者：
Britton, J
DOI：
10.4269/ajtmh.2009.09-0237
发表时间：
2009-11-01
影响因子：
3.3
作者：
Blount, Daniel;Hooi, Doreen;Pritchard, David
通讯作者：
Pritchard, David
影响因子：
11.2
作者：
Correale, Jorge;Farez, Mauricio
通讯作者：
Farez, Mauricio
影响因子：
14.2
作者：
LYNCH, NR;HAGEL, I;ALVAREZ, N
通讯作者：
ALVAREZ, N