Parvalbumin‐containing neurons, perineuronal nets and experience‐dependent plasticity in murine barrel cortex
Parvalbumin‐containing neurons, perineuronal nets and experience‐dependent plasticity in murine barrel cortex
复制标题
小鼠桶状皮层中含有小清蛋白的神经元、神经周围网和经验依赖性可塑性
DOI：
10.1111/j.1460-9568.2009.06996.x
复制
发表时间：
2009
影响因子：
3.4
通讯作者：
S. Glazewski
中科院分区：
文献类型：
--
作者：
D. Nowicka;S. Soulsby;J. Skangiel‐Kramska;S. Glazewski
在新皮质中经历经验依赖性可塑性的能力通常局限于早期发育，但也限于特定的皮质部位和特定的经验。在桶状皮质的II-IV层，除一根触须外，所有触须的可塑性(单触须培养)没有时间限制，但IV层桶除外，只能在出生后第一周诱导。相比之下，剥夺每一秒的触觉(棋盘剥夺)可以消除可塑性的时间限制。当棋盘被剥夺时，允许可塑性的机制是未知的，而在单细胞培养时，这种可塑性被阻止的机制尚不清楚。硫酸软骨素蛋白多糖凝聚成神经周围神经网络和含有小白蛋白的中间神经元介导的皮质内抑制增加是眼优势可塑性关键期的结束。这些因素也可能涉及到以一种取决于特定感官体验的方式来设定桶中的关键时期。因此，我们研究了在小鼠桶状皮质发育过程中以及在青春期短暂的单细胞和棋盘经历后，含有小白蛋白的细胞和神经周围神经网络密度的变化。我们观察到，在出生后第10天到第20天，这两个标记在皮质层中的密度逐渐增加，这在桶中尤其明显。饲养Univiviissa，而不是剥夺棋盘，增加了被剥夺的桶中神经周围网和含有小白蛋白的细胞的密度，但只增加了那些紧邻未被剥夺的桶的密度。这些数据表明，这两个被测试的因素都参与了以依赖经验的方式关闭桶内临界期的过程。
The ability to undergo experience‐dependent plasticity in the neocortex is often limited to early development, but also to particular cortical loci and specific experience. In layers II–IV of the barrel cortex, plasticity evoked by removing all but one vibrissae (univibrissa rearing) does not have a time limit except for layer IV barrels, where it can only be induced during the first postnatal week. In contrast, deprivation of every second vibrissa (chessboard deprivation) removes time limits for plasticity. The mechanism permitting plasticity in response to chessboard deprivation and halting it in reply to univibrissa rearing is unknown. Condensation of chondroitin sulfate proteoglycans into perineuronal nets and an increase in intracortical inhibition mediated by parvalbumin‐containing interneurons are implicated in closing the critical period for ocular dominance plasticity. These factors could also be involved in setting up the critical period in barrels in a way that depends on a particular sensory experience. We therefore examined changes in density of parvalbumin‐containing cells and perineuronal nets during development of mouse barrel cortex and after brief univibrissa and chessboard experience in adolescence. We observed a progressive increase in the density of the two markers across cortical layers between postnatal day 10 and 20, which was especially pronounced in the barrels. Univibrissa rearing, but not chessboard deprivation, increased the density of perineuronal nets and parvalbumin‐containing cells in the deprived barrels, but only those that immediately neighbour the undeprived barrel. These data suggest the involvement of both tested factors in closing the critical period in barrels in an experience‐dependent manner.
影响因子：
56.9
作者：
Hensch, TK;Fagiolini, M;Kash, SF
通讯作者：
Kash, SF
DOI：
10.1016/0165-3806(91)90001-y
发表时间：
1991-02-22
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
MOWER, GD
通讯作者：
MOWER, GD